Detailed information of TA system TA029896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5430619..5431114
• Replicon: chromosome
• Accession: NC_021985
• Organism: Streptomyces collinus Tu 365

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S5VLW5
• Locus tag: B446_RS23780
• Protein ID: WP_020941979.1
• Coordinates: 5430619..5430852 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5UWF1
• Locus tag: B446_RS23785
• Protein ID: WP_019434848.1
• Coordinates: 5430845..5431114 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B446_RS23755	5426351..5426533	-	183	WP_020941974.1	hypothetical protein	-
B446_RS23760	5426865..5427890	+	1026	WP_106960598.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
B446_RS23765	5427955..5428707	+	753	WP_020941976.1	ROK family protein	-
B446_RS23770	5428720..5429265	-	546	WP_193384489.1	hypothetical protein	-
B446_RS23775	5429446..5430534	+	1089	WP_020941978.1	redox-regulated ATPase YchF	-
B446_RS23780	5430619..5430852	-	234	WP_020941979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B446_RS23785	5430845..5431114	-	270	WP_019434848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B446_RS23790	5431232..5431745	-	514	Protein_4742	Uma2 family endonuclease	-
B446_RS23795	5432135..5435131	+	2997	WP_020941981.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8929.35 Da
• Isoelectric Point: 10.1504

>T29896 WP_020941979.1 NC_021985:c5430852-5430619 [Streptomyces collinus Tu 365]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTVLETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVAR

Nucleotide

• Length: 234 bp

>T29896 NC_021985:c5430852-5430619 [Streptomyces collinus Tu 365]
GTGAGTGAGTACCGAACCGTCTTCCGCCCCGAGGCGCAGGCCGAGCTTCGGAAGATCCCCCGCGACATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGTGTTGGAGACCGACCCTCTCGGCTTCAACACCACCGCACTCGTGTCACAGCCCGAACGACGCC
GTCTTCGCGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGCGAGCTGGTGGTCTGGGTCGCACGGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10227.65 Da
• Isoelectric Point: 4.6265

>AT29896 WP_019434848.1 NC_021985:c5431114-5430845 [Streptomyces collinus Tu 365]
VTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT29896 NC_021985:c5431114-5430845 [Streptomyces collinus Tu 365]
GTGACGCAGCCACTGCCCATAGAGTCCATTCGCGACGTGCGAGCACACCTGGCGGAGGTCGTGGAGCGCGCAGACCGCGA
CGATGTACCCACGGTGATCACACGCCGAGGCAAGGAAGTCGCGGCCGTCGTCTCCATTGAGGTTCTGCGCAAGTATCAGG
AGTGGGAAGAGCGCGAGATCAATCGGATCATCGACGAGCGCATGGCCAACCCCGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Structures

Toxin

• AlphaFold DB: S5VLW5

Antitoxin

• AlphaFold DB: S5UWF1