Detailed information of TA system TA029891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2203318..2204843
• Replicon: chromosome
• Accession: NC_021917
• Organism: Cycloclasticus zancles 7-ME

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: CYCME_RS10505
• Protein ID: WP_020933003.1
• Coordinates: 2203318..2204571 (-)
• Length: 418 a.a.

Antitoxin (Protein)

• Gene name: HipB2
• Uniprot ID: S5TA57
• Locus tag: CYCME_RS10510
• Protein ID: WP_020933004.1
• Coordinates: 2204568..2204843 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYCME_RS10490	2198375..2198836	-	462	WP_020933000.1	type I-E CRISPR-associated protein Cse2/CasB	-
CYCME_RS10495	2198829..2200340	-	1512	WP_020933001.1	type I-E CRISPR-associated protein Cse1/CasA	-
CYCME_RS10500	2200337..2203060	-	2724	WP_020933002.1	CRISPR-associated helicase/endonuclease Cas3	-
CYCME_RS10505	2203318..2204571	-	1254	WP_020933003.1	type II toxin-antitoxin system HipA family toxin	Toxin
CYCME_RS10510	2204568..2204843	-	276	WP_020933004.1	helix-turn-helix transcriptional regulator	Antitoxin
CYCME_RS10520	2205399..2206073	-	675	WP_015005290.1	7-cyano-7-deazaguanine synthase QueC	-
CYCME_RS10525	2206094..2206741	-	648	WP_020933005.1	7-carboxy-7-deazaguanine synthase QueE	-
CYCME_RS10530	2206772..2207566	-	795	WP_020933006.1	tol-pal system protein YbgF	-
CYCME_RS10535	2207563..2208096	-	534	WP_016389856.1	OmpA family protein	-
CYCME_RS10540	2208113..2209411	-	1299	WP_020933007.1	Tol-Pal system beta propeller repeat protein TolB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Transcription regulator, HipB-like (14-70)

Sequences

Toxin

Protein

• Length: 418 a.a.
• Molecular weight: 46938.15 Da
• Isoelectric Point: 6.7627

>T29891 WP_020933003.1 NC_021917:c2204571-2203318 [Cycloclasticus zancles 78-ME]
MSQVLDVYLSAERVGKLHLDDERRFVFEYYPEWVENHESQPISLSLPVRTEPYHHARAQPFFSNLLPEAEIRYLVAKSLG
LSENNDFSLLEAIGGECAGAVSLIPEGTGIPIQGDYKKLNDNALNQLIAKLPTQPMLTGEQDIRLSLAGAQNKLPVFYNG
KEISIPRGAAASSHILKLPIKDYPNTVENEYFCMQLAKRIGLNVPETKILHKVAPLYLITRYDRILNEQGELIRLPQEDF
CQAMAIPPINKYEKEGGPSLKSCFDLVRNHGIQPVKDLNELLNWVIFNVLIGNADAHGKNISLMLTSAGPLLAPFYDLMS
TAIYPNLAQKMAMKIGGEDRPDWIIERRWEQFSKDTGIKFKLVRKRCIDMANTLSTISVELAAECQQQHGENVQIKKIVA
LIEQRKSKINAIFSSIN

Nucleotide

• Length: 1254 bp

>T29891 NC_021917:c2204571-2203318 [Cycloclasticus zancles 78-ME]
ATGAGCCAAGTGCTTGACGTGTACCTATCAGCAGAACGTGTAGGCAAATTACACTTAGATGATGAACGACGCTTTGTATT
TGAATACTATCCTGAGTGGGTTGAAAATCATGAGTCACAGCCAATTTCGCTAAGCTTACCGGTACGAACTGAACCTTATC
ATCATGCACGTGCCCAACCGTTTTTCTCTAATTTACTACCTGAAGCAGAAATAAGGTATTTAGTCGCAAAAAGTTTGGGC
TTATCTGAAAACAATGATTTTTCCCTATTAGAAGCCATTGGGGGAGAGTGTGCCGGTGCTGTGAGCTTGATCCCGGAAGG
AACAGGCATCCCAATACAAGGTGATTATAAAAAACTTAATGATAATGCGTTAAATCAATTAATCGCAAAGTTGCCAACAC
AGCCGATGCTGACCGGTGAACAGGATATTAGATTATCGCTAGCTGGCGCACAAAACAAGCTACCCGTTTTTTATAATGGT
AAAGAAATAAGCATACCAAGGGGAGCAGCGGCGAGTAGCCATATTTTAAAACTGCCCATAAAGGATTACCCTAATACCGT
TGAAAATGAATATTTCTGTATGCAGTTGGCTAAAAGGATAGGCCTAAACGTTCCCGAAACAAAAATTCTTCATAAAGTAG
CCCCGCTATATCTCATCACACGTTATGATCGTATTCTTAATGAGCAAGGTGAGTTAATACGGTTGCCTCAAGAAGATTTT
TGCCAGGCAATGGCCATTCCCCCTATTAACAAGTATGAAAAAGAAGGTGGCCCAAGCCTAAAGTCATGTTTTGACTTAGT
ACGCAACCATGGTATTCAGCCAGTCAAAGATTTAAACGAACTTCTCAATTGGGTGATTTTCAATGTATTAATTGGCAATG
CCGATGCTCACGGCAAAAATATTTCGCTTATGCTAACCTCGGCAGGGCCGCTATTAGCCCCCTTTTATGACCTGATGAGC
ACAGCCATCTACCCTAATTTAGCTCAAAAAATGGCCATGAAAATAGGTGGGGAAGACAGGCCCGATTGGATTATTGAGAG
GCGTTGGGAACAGTTCTCAAAAGACACCGGTATCAAATTTAAGCTCGTTAGGAAAAGGTGTATAGACATGGCGAATACAC
TATCGACAATATCAGTTGAATTGGCAGCTGAGTGCCAGCAACAACATGGCGAGAATGTTCAAATTAAAAAAATAGTCGCG
TTAATTGAGCAGCGTAAAAGCAAGATAAATGCAATTTTCAGCTCAATTAATTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9642.07 Da
• Isoelectric Point: 9.3476

>AT29891 WP_020933004.1 NC_021917:c2204843-2204568 [Cycloclasticus zancles 78-ME]
MTTLPSGKILSAQALGDIVRQQRKRQGATQVELASLCGVGVRFISDLENGKQTIELGKVLQVLNSLGLELAIQPRGWTHS
SFTVDAPGGPS

Nucleotide

• Length: 276 bp

>AT29891 NC_021917:c2204843-2204568 [Cycloclasticus zancles 78-ME]
ATGACAACATTACCGAGCGGGAAAATATTAAGCGCGCAAGCATTGGGTGATATCGTGCGACAGCAACGGAAGCGACAGGG
TGCAACACAAGTTGAATTAGCGTCGTTATGTGGTGTGGGAGTGCGATTTATATCTGATTTGGAAAATGGGAAACAAACAA
TTGAACTGGGTAAGGTCTTACAAGTGCTGAATAGCTTAGGCCTAGAGTTGGCAATTCAGCCTAGAGGCTGGACACACTCA
AGCTTCACGGTTGATGCGCCAGGTGGGCCATCATGA

Structures

Antitoxin

• AlphaFold DB: S5TA57