Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 204185..204792 Replicon plasmid pRetMIM1f
Accession NC_021911
Organism Rhizobium etli bv. mimosae str. Mim1

Toxin (Protein)


Gene name hicA Uniprot ID S5SES5
Locus tag REMIM1_RS30385 Protein ID WP_020919230.1
Coordinates 204538..204792 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID S5S7D6
Locus tag REMIM1_RS30380 Protein ID WP_020919229.1
Coordinates 204185..204541 (-) Length 119 a.a.

Genomic Context

REMIM1_RS30360REMIM1_RS36260REMIM1_RS36265REMIM1_RS30355REMIM1_RS36885REMIM1_RS30375REMIM1_RS30380REMIM1_RS30385REMIM1_RS30395REMIM1_RS30400REMIM1_RS30405REMIM1_RS30410REMIM1_RS30415
Location: 200119..201057 (939 bp)
Type: Others
Protein ID: Protein_186
Location: 201315..201665 (351 bp)
Type: Others
Protein ID: Protein_187
Location: 205077..205544 (468 bp)
Type: Others
Protein ID: WP_080655890.1
Location: 199263..199475 (213 bp)
Type: Others
Protein ID: WP_020919226.1
Location: 201755..202387 (633 bp)
Type: Others
Protein ID: WP_020919227.1
Location: 202400..203606 (1207 bp)
Type: Others
Protein ID: Protein_189
Location: 204185..204541 (357 bp)
Type: Antitoxin
Protein ID: WP_020919229.1
Location: 204538..204792 (255 bp)
Type: Toxin
Protein ID: WP_020919230.1
Location: 205609..206334 (726 bp)
Type: Others
Protein ID: WP_020919231.1
Location: 206467..206799 (333 bp)
Type: Others
Protein ID: WP_020919232.1
Location: 206890..207570 (681 bp)
Type: Others
Protein ID: WP_041679287.1
Location: 207589..208284 (696 bp)
Type: Others
Protein ID: WP_041679372.1
Location: 208287..209240 (954 bp)
Type: Others
Protein ID: WP_020919235.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
REMIM1_RS30355199263..199475-213WP_020919226.1DUF2283 domain-containing protein-
REMIM1_RS30360200119..201057+939Protein_186ISNCY family transposase-
REMIM1_RS36260201315..201665+351Protein_187IS30 family transposase-
REMIM1_RS36885201755..202387-633WP_020919227.1DUF433 domain-containing protein-
REMIM1_RS30375202400..203606-1207Protein_189putative DNA binding domain-containing protein-
REMIM1_RS30380204185..204541-357WP_020919229.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
REMIM1_RS30385204538..204792-255WP_020919230.1type II toxin-antitoxin system HicA family toxinToxin
REMIM1_RS36265205077..205544+468WP_080655890.1IS5 family transposase-
REMIM1_RS30395205609..206334-726WP_020919231.1response regulator-
REMIM1_RS30400206467..206799-333WP_020919232.1hypothetical protein-
REMIM1_RS30405206890..207570-681WP_041679287.1NnrU family protein-
REMIM1_RS30410207589..208284-696WP_041679372.1Crp/Fnr family transcriptional regulator-
REMIM1_RS30415208287..209240-954WP_020919235.1formylglycine-generating enzyme family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid-htpB1..10826591082659
-flankIS/Tn--200113..201057944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9345.71 Da        Isoelectric Point: 8.6586

>T29887 WP_020919230.1 NC_021911:c204792-204538 [Rhizobium etli bv. mimosae str. Mim1]
MNSKQRKTLAAVFKDPVSGTIEWAAIENLLVAAGADLIEGNGSRVKFEKDEIIASFHRPHPAKEAKRYQVRDAHEFLMQI
GVTP

Download         Length: 255 bp

>T29887 NC_021911:c204792-204538 [Rhizobium etli bv. mimosae str. Mim1]
ATGAACAGCAAGCAAAGAAAGACTCTCGCGGCGGTCTTCAAGGACCCAGTCTCGGGAACCATTGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGAGCCGACCTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGAGATCATTG
CGAGCTTCCATCGACCACATCCGGCCAAGGAAGCGAAGCGTTATCAGGTGCGCGATGCTCACGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13227.94 Da        Isoelectric Point: 5.5750

>AT29887 WP_020919229.1 NC_021911:c204541-204185 [Rhizobium etli bv. mimosae str. Mim1]
MNIMTYNGYHARIAFDAEDDLFFGRIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAANHFAEARLPA

Download         Length: 357 bp

>AT29887 NC_021911:c204541-204185 [Rhizobium etli bv. mimosae str. Mim1]
ATGAACATCATGACCTACAACGGATATCACGCTCGCATCGCATTCGACGCTGAGGACGATCTGTTTTTCGGCAGGATTGC
AGGTATCTCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCAGTCGATGACT
ACCTGGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTGAACCAGTGGGCAGAAGAGGTGCTGGAAGAGGC
CGCCAACCATTTTGCCGAGGCGCGCTTGCCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS5SES5

Antitoxin

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Source
ID
Structure
AlphaFold DBS5S7D6

References