Detailed information of TA system TA029874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1344253..1344873
• Replicon: chromosome
• Accession: NC_021900
• Organism: Streptococcus lutetiensis 033

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KE3_RS06730
• Protein ID: WP_043895076.1
• Coordinates: 1344688..1344873 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S5QY49
• Locus tag: KE3_RS06725
• Protein ID: WP_020917105.1
• Coordinates: 1344253..1344630 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KE3_RS06710	1339943..1341463	-	1521	WP_020917103.1	zinc ABC transporter substrate-binding protein AdcA	-
KE3_RS06715	1341644..1342643	+	1000	Protein_1277	IS30 family transposase	-
KE3_RS06720	1342752..1344164	-	1413	WP_020917104.1	C69 family dipeptidase	-
KE3_RS06725	1344253..1344630	-	378	WP_020917105.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KE3_RS06730	1344688..1344873	-	186	WP_043895076.1	type II toxin-antitoxin system HicA family toxin	Toxin
KE3_RS10020	1345148..1345945	-	798	WP_020917107.1	lysin	-
KE3_RS06745	1345942..1346268	-	327	WP_020917108.1	phage holin	-
KE3_RS06750	1346281..1346613	-	333	WP_020917109.1	hypothetical protein	-
KE3_RS10600	1346635..1346793	-	159	WP_020917110.1	hypothetical protein	-
KE3_RS06760	1346819..1347160	-	342	WP_020917111.1	DUF1366 domain-containing protein	-
KE3_RS06765	1347173..1349239	-	2067	WP_020917112.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1332230..1382249	50019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-101)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6914.17 Da
• Isoelectric Point: 10.7447

>T29874 WP_043895076.1 NC_021900:c1344873-1344688 [Streptococcus lutetiensis 033]
MPMTPKQMIKLLKKNGFYEVGQRGSHKKFRDDKGHQTIVPLHNKDLGKGLEDAILKQAGLK

Nucleotide

• Length: 186 bp

>T29874 NC_021900:c1344873-1344688 [Streptococcus lutetiensis 033]
ATGCCAATGACCCCTAAGCAGATGATAAAATTGCTTAAAAAGAACGGGTTTTACGAAGTCGGTCAACGTGGAAGTCACAA
GAAATTCCGAGATGACAAAGGACACCAAACAATTGTGCCACTGCACAATAAAGACCTTGGTAAAGGTCTTGAAGATGCTA
TTTTAAAACAAGCAGGTTTAAAATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14369.41 Da
• Isoelectric Point: 4.0862

>AT29874 WP_020917105.1 NC_021900:c1344630-1344253 [Streptococcus lutetiensis 033]
MLVYPALFTQDGDYILVTFPDIPEAITQGKDIQEAFEMATEVLGFALEDYKEYPKPTSPSDLKEQFPDSYIALIQIDMLA
YMKKYHANKVRKNVTIPEWLNELAEENNVNFSQVLTEALEMKLQA

Nucleotide

• Length: 378 bp

>AT29874 NC_021900:c1344630-1344253 [Streptococcus lutetiensis 033]
ATGTTAGTTTATCCAGCTTTATTTACTCAAGATGGCGATTATATTCTTGTAACTTTTCCAGACATCCCTGAGGCTATCAC
TCAAGGAAAAGATATCCAAGAAGCTTTTGAAATGGCTACAGAGGTTCTAGGGTTTGCGCTTGAAGATTACAAAGAATACC
CAAAACCAACTTCGCCATCAGATTTGAAAGAGCAATTTCCTGATAGTTATATTGCATTGATTCAAATTGATATGCTAGCG
TATATGAAAAAATATCACGCAAACAAAGTTCGCAAAAATGTAACTATCCCAGAATGGTTAAACGAACTCGCAGAAGAGAA
CAATGTCAACTTCTCACAAGTTCTTACTGAAGCTCTTGAAATGAAATTACAAGCTTAA

Structures

Antitoxin

• AlphaFold DB: S5QY49