Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3768179..3769220 | Replicon | chromosome |
| Accession | NC_021884 | ||
| Organism | Burkholderia pseudomallei MSHR305 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | BDL_RS30855 | Protein ID | WP_004539802.1 |
| Coordinates | 3768645..3769220 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0E1SLI7 |
| Locus tag | BDL_RS30850 | Protein ID | WP_004540053.1 |
| Coordinates | 3768179..3768640 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BDL_RS30825 | 3763785..3764453 | - | 669 | WP_012730038.1 | restriction endonuclease fold toxin 5 domain-containing protein | - |
| BDL_RS30835 | 3764738..3765244 | - | 507 | WP_004539924.1 | DUF4123 domain-containing protein | - |
| BDL_RS30840 | 3765241..3765666 | - | 426 | WP_004539640.1 | PAAR domain-containing protein | - |
| BDL_RS40905 | 3766064..3766444 | - | 381 | WP_020850431.1 | hypothetical protein | - |
| BDL_RS39465 | 3766904..3767131 | - | 228 | WP_004540114.1 | hypothetical protein | - |
| BDL_RS40910 | 3767128..3767526 | - | 399 | WP_133604798.1 | hypothetical protein | - |
| BDL_RS30850 | 3768179..3768640 | + | 462 | WP_004540053.1 | excisionase family DNA-binding protein | Antitoxin |
| BDL_RS30855 | 3768645..3769220 | + | 576 | WP_004539802.1 | PIN domain-containing protein | Toxin |
| BDL_RS39475 | 3769406..3771622 | + | 2217 | WP_004540097.1 | ATP-binding protein | - |
| BDL_RS30860 | 3772871..3773050 | + | 180 | WP_004191077.1 | hypothetical protein | - |
| BDL_RS30865 | 3773234..3773506 | + | 273 | WP_004527347.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22056.35 Da Isoelectric Point: 6.4079
>T29873 WP_004539802.1 NC_021884:3768645-3769220 [Burkholderia pseudomallei MSHR305]
MSSNFTVVYDACVLYPAPLRDLLMHLAVTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAAIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPRERVGKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMANQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLAVTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAAIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPRERVGKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMANQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T29873 NC_021884:3768645-3769220 [Burkholderia pseudomallei MSHR305]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GGTGACGGATCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTGGAAAACTTCGAG
CATCTGATTGCGGCGATCGAGTTGCCCGATCCTGATGATCGTCATGTCGTCGCGGCAGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAGGGAGCGGGTCGGAAAGTACAACGTGTCGGCTCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAACCCG
CCGAAGTCAGTGGAAGACTATCTCGACACGATGGCCAATCAGGGACTCGTGCAGACGGTCGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GGTGACGGATCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTGGAAAACTTCGAG
CATCTGATTGCGGCGATCGAGTTGCCCGATCCTGATGATCGTCATGTCGTCGCGGCAGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAGGGAGCGGGTCGGAAAGTACAACGTGTCGGCTCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAACCCG
CCGAAGTCAGTGGAAGACTATCTCGACACGATGGCCAATCAGGGACTCGTGCAGACGGTCGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17155.41 Da Isoelectric Point: 5.5474
>AT29873 WP_004540053.1 NC_021884:3768179-3768640 [Burkholderia pseudomallei MSHR305]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT29873 NC_021884:3768179-3768640 [Burkholderia pseudomallei MSHR305]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|