Detailed information of TA system TA029872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2817942..2818498
• Replicon: chromosome
• Accession: NC_021884
• Organism: Burkholderia pseudomallei MSHR305

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BDL_RS26420
• Protein ID: WP_023594135.1
• Coordinates: 2818208..2818498 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: BDL_RS26415
• Protein ID: WP_004541313.1
• Coordinates: 2817942..2818220 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BDL_RS38685	2813843..2814739	-	897	WP_020850700.1	hypothetical protein	-
BDL_RS38690	2814817..2815074	-	258	WP_004541318.1	hypothetical protein	-
BDL_RS26405	2815565..2815834	+	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
BDL_RS26410	2815837..2817861	+	2025	WP_196043030.1	relaxase/mobilization nuclease domain-containing protein	-
BDL_RS26415	2817942..2818220	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
BDL_RS26420	2818208..2818498	+	291	WP_023594135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BDL_RS26425	2818495..2818815	+	321	WP_197540451.1	hypothetical protein	-
BDL_RS40815	2819011..2819259	+	249	WP_004541364.1	hypothetical protein	-
BDL_RS41975	2819364..2820023	+	660	WP_020850627.1	hypothetical protein	-
BDL_RS26440	2820065..2822266	-	2202	WP_004541389.1	AAA family ATPase	-
BDL_RS26445	2822493..2823014	-	522	WP_004541357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2810364..2827512	17148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10892.45 Da
• Isoelectric Point: 9.5554

>T29872 WP_023594135.1 NC_021884:2818208-2818498 [Burkholderia pseudomallei MSHR305]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T29872 NC_021884:2818208-2818498 [Burkholderia pseudomallei MSHR305]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGTCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCGTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT29872 WP_004541313.1 NC_021884:2817942-2818220 [Burkholderia pseudomallei MSHR305]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT29872 NC_021884:2817942-2818220 [Burkholderia pseudomallei MSHR305]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0