29868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1832850..1833389 Replicon chromosome
Accession NC_021883
Organism Mannheimia haemolytica USMARC 2286

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag N220_RS09250 Protein ID WP_006247804.1
Coordinates 1833120..1833389 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag N220_RS09245 Protein ID WP_006247803.1
Coordinates 1832850..1833116 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N220_RS09205 1828250..1828885 - 636 Protein_1822 transposase -
N220_RS09210 1828986..1829696 - 711 Protein_1823 tyrosine-type recombinase/integrase -
N220_RS13735 1829600..1829923 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
N220_RS09215 1830004..1830171 - 168 WP_006253314.1 DNA cytosine methyltransferase -
N220_RS09220 1830179..1830553 - 375 WP_006247798.1 hypothetical protein -
N220_RS13740 1830703..1830930 + 228 Protein_1827 phage terminase large subunit family protein -
N220_RS09225 1830955..1831350 + 396 WP_006247799.1 phage tail protein -
N220_RS09230 1831382..1832023 + 642 WP_006247800.1 hypothetical protein -
N220_RS09235 1832106..1832507 + 402 WP_006247801.1 hypothetical protein -
N220_RS09240 1832552..1832782 + 231 WP_006247802.1 DUF4035 domain-containing protein -
N220_RS09245 1832850..1833116 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N220_RS09250 1833120..1833389 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
N220_RS09255 1833464..1833727 + 264 WP_006247805.1 hypothetical protein -
N220_RS09260 1833787..1834497 + 711 WP_006253312.1 tape measure protein -
N220_RS09265 1834475..1834765 + 291 Protein_1836 C40 family peptidase -
N220_RS09270 1834755..1835474 + 720 WP_006247806.1 preprotein translocase subunit YajC -
N220_RS09280 1835696..1836322 + 627 WP_006247807.1 tail assembly protein -
N220_RS09285 1836371..1836982 + 612 WP_006253310.1 hypothetical protein -
N220_RS09290 1837093..1837779 + 687 WP_006247808.1 hypothetical protein -
N220_RS13960 1837789..1837947 + 159 WP_006247809.1 hypothetical protein -
N220_RS09295 1837956..1838255 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1818943..1843017 24074
- flank IS/Tn - - 1828193..1828885 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T29868 WP_006247804.1 NC_021883:1833120-1833389 [Mannheimia haemolytica USMARC_2286]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T29868 NC_021883:1833120-1833389 [Mannheimia haemolytica USMARC_2286]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT29868 WP_006247803.1 NC_021883:1832850-1833116 [Mannheimia haemolytica USMARC_2286]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT29868 NC_021883:1832850-1833116 [Mannheimia haemolytica USMARC_2286]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References