Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1243164..1243788 Replicon chromosome
Accession NC_021882
Organism Helicobacter pylori UM298

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K748_RS06160 Protein ID WP_000916178.1
Coordinates 1243522..1243788 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K748_RS06155 Protein ID WP_015644924.1
Coordinates 1243164..1243541 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K748_RS06125 1238309..1239421 + 1113 WP_015644921.1 hydrogenase formation protein HypD -
K748_RS06130 1239372..1240022 - 651 Protein_1167 hypothetical protein -
K748_RS06150 1240415..1242640 + 2226 WP_015644923.1 Hop family adhesin BabA -
K748_RS06155 1243164..1243541 + 378 WP_015644924.1 hypothetical protein Antitoxin
K748_RS06160 1243522..1243788 + 267 WP_000916178.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K748_RS06165 1243893..1244417 - 525 WP_001120212.1 acyl-CoA thioesterase -
K748_RS06170 1244558..1245406 + 849 WP_015644925.1 SDR family oxidoreductase -
K748_RS06175 1245399..1246379 + 981 WP_015644926.1 iron ABC transporter permease -
K748_RS06180 1246379..1247146 + 768 WP_000242365.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10273.15 Da        Isoelectric Point: 9.9840

>T29864 WP_000916178.1 NC_021882:1243522-1243788 [Helicobacter pylori UM298]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRGDELILVR
LGSHSELF

Download         Length: 267 bp

>T29864 NC_021882:1243522-1243788 [Helicobacter pylori UM298]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTACTTGTGTATTTGGTGAGAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14775.81 Da        Isoelectric Point: 9.4267

>AT29864 WP_015644924.1 NC_021882:1243164-1243541 [Helicobacter pylori UM298]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKRMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT29864 NC_021882:1243164-1243541 [Helicobacter pylori UM298]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAGATCAAAAGGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACTGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References