Detailed information of TA system TA029863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1297472..1298051
• Replicon: chromosome
• Accession: NC_021878
• Organism: Arcobacter butzleri 7h1h

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S5PV56
• Locus tag: A7H1H_RS06610
• Protein ID: WP_020848068.1
• Coordinates: 1297752..1298051 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A7H1H_RS06605
• Protein ID: WP_020848067.1
• Coordinates: 1297472..1297759 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7H1H_RS06595	1292818..1293906	-	1089	WP_020848065.1	site-specific integrase	-
A7H1H_RS06600	1294349..1297450	+	3102	WP_020848066.1	hypothetical protein	-
A7H1H_RS06605	1297472..1297759	-	288	WP_020848067.1	putative addiction module antidote protein	Antitoxin
A7H1H_RS06610	1297752..1298051	-	300	WP_020848068.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7H1H_RS06615	1298289..1298696	-	408	WP_020848069.1	Rrf2 family transcriptional regulator	-
A7H1H_RS06620	1298842..1301076	+	2235	WP_020848070.1	cbb3-type cytochrome c oxidase subunit I	-
A7H1H_RS06625	1301108..1301677	-	570	WP_020848071.1	hypothetical protein	-
A7H1H_RS06630	1301674..1302843	-	1170	WP_020848072.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11416.22 Da
• Isoelectric Point: 9.6906

>T29863 WP_020848068.1 NC_021878:c1298051-1297752 [Arcobacter butzleri 7h1h]
MYIIKQTNIFSKWLLKLKDTQGKVSILRRIDRMKLGNFGDCKSVGNNISELRITTSTAYRVYYTKKDEEIIVLLIGGDKS
TQSDDIKKANEILKELDNE

Nucleotide

• Length: 300 bp

>T29863 NC_021878:c1298051-1297752 [Arcobacter butzleri 7h1h]
ATGTACATAATAAAACAAACAAATATTTTTTCAAAATGGTTATTAAAACTAAAAGATACTCAAGGTAAGGTTTCAATATT
ACGAAGAATTGACAGAATGAAACTTGGTAACTTTGGAGATTGTAAATCTGTAGGTAATAATATATCTGAACTAAGAATTA
CAACAAGTACAGCTTATAGAGTTTACTATACTAAAAAAGATGAAGAGATTATTGTTTTATTAATTGGTGGAGATAAATCA
ACACAAAGTGATGATATAAAAAAAGCAAATGAAATTTTAAAGGAGCTAGATAATGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10626.19 Da
• Isoelectric Point: 5.1351

>AT29863 WP_020848067.1 NC_021878:c1297759-1297472 [Arcobacter butzleri 7h1h]
MSKLEITNFDIAQYLDDKEVIAEYLSQILSDGNTDELLEALGNIAKAKGMSQLAKDTGLGRESLYKTFQKGTKPKFETIK
KVLDSFGIRMQVTAY

Nucleotide

• Length: 288 bp

>AT29863 NC_021878:c1297759-1297472 [Arcobacter butzleri 7h1h]
ATGAGTAAACTAGAAATTACAAATTTTGATATAGCACAATACCTTGATGATAAAGAAGTAATAGCAGAATATTTATCTCA
AATATTAAGTGATGGAAATACAGATGAATTATTAGAAGCTTTAGGAAATATTGCTAAAGCAAAAGGTATGAGCCAATTAG
CAAAAGATACTGGACTAGGTAGAGAGAGTTTATATAAAACATTTCAAAAAGGTACAAAACCTAAATTTGAAACAATAAAA
AAGGTATTGGATTCTTTTGGTATTAGAATGCAAGTTACAGCCTACTAA

Structures

Toxin

• AlphaFold DB: S5PV56