Detailed information of TA system TA029862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1290361..1290886
• Replicon: chromosome
• Accession: NC_021878
• Organism: Arcobacter butzleri 7h1h

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S5PV53
• Locus tag: A7H1H_RS06585
• Protein ID: WP_020848063.1
• Coordinates: 1290602..1290886 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5P5M8
• Locus tag: A7H1H_RS06580
• Protein ID: WP_020848062.1
• Coordinates: 1290361..1290612 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7H1H_RS06565	1287121..1288209	-	1089	WP_144062844.1	restriction endonuclease	-
A7H1H_RS06570	1288319..1289926	-	1608	WP_020848060.1	DNA cytosine methyltransferase	-
A7H1H_RS06575	1289960..1290187	-	228	WP_020848061.1	tyrosine-type recombinase/integrase	-
A7H1H_RS06580	1290361..1290612	+	252	WP_020848062.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A7H1H_RS06585	1290602..1290886	+	285	WP_020848063.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7H1H_RS06590	1291080..1292576	-	1497	WP_020848064.1	FRG domain-containing protein	-
A7H1H_RS06595	1292818..1293906	-	1089	WP_020848065.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11216.12 Da
• Isoelectric Point: 10.1830

>T29862 WP_020848063.1 NC_021878:1290602-1290886 [Arcobacter butzleri 7h1h]
MTYNLEFKPQALKEWSKLGSTIKEQFKKKLEERLENPKVEKDKLSGYENVYKIKLKTAGYRLAYQVKDEEIVVLVLSVGK
REKDKIYKNLKDRF

Nucleotide

• Length: 285 bp

>T29862 NC_021878:1290602-1290886 [Arcobacter butzleri 7h1h]
ATGACTTATAATCTTGAATTTAAACCTCAAGCTTTAAAAGAGTGGAGTAAATTAGGCTCAACAATAAAAGAACAATTTAA
AAAGAAATTAGAAGAAAGACTTGAAAATCCCAAAGTAGAAAAAGATAAACTAAGTGGATATGAAAATGTTTATAAAATAA
AATTAAAAACTGCTGGATATAGACTTGCTTACCAAGTTAAAGATGAAGAAATAGTTGTTTTAGTATTGAGTGTTGGAAAA
AGGGAAAAAGATAAAATTTATAAGAATCTAAAAGATAGATTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9267.63 Da
• Isoelectric Point: 4.3696

>AT29862 WP_020848062.1 NC_021878:1290361-1290612 [Arcobacter butzleri 7h1h]
MQPILANYSASITELKKSPTQLLNEADNEVIAILNHNIPSAYLVPSKLYEKMMDIIDDYHLSLEVGKALNDGEKPVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT29862 NC_021878:1290361-1290612 [Arcobacter butzleri 7h1h]
ATGCAACCAATTTTAGCAAATTATAGTGCAAGTATAACAGAACTTAAAAAATCTCCTACACAATTACTAAATGAAGCAGA
TAATGAAGTTATAGCAATATTAAATCATAATATCCCTAGTGCTTATCTAGTTCCAAGTAAACTTTATGAAAAAATGATGG
ATATTATAGATGATTATCATTTGTCATTAGAAGTTGGAAAAGCTTTAAATGATGGTGAAAAACCAGTTAAAGTAAATTTA
GATGACTTATAA

Structures

Toxin

• AlphaFold DB: S5PV53

Antitoxin

• AlphaFold DB: S5P5M8