Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1065274..1065929 Replicon chromosome
Accession NC_021877
Organism Burkholderia pseudomallei MSHR305

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BDL_RS04315 Protein ID WP_006027262.1
Coordinates 1065274..1065570 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BDL_RS04320 Protein ID WP_004202809.1
Coordinates 1065573..1065929 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BDL_RS04305 1060284..1061648 + 1365 WP_020850121.1 GGDEF domain-containing protein -
BDL_RS04310 1061759..1064008 + 2250 WP_009979045.1 glycosyltransferase -
BDL_RS33505 1063935..1064648 + 714 WP_080002914.1 cellulose biosynthesis protein BcsS -
BDL_RS04315 1065274..1065570 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BDL_RS04320 1065573..1065929 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BDL_RS04325 1065973..1066122 - 150 WP_004542845.1 hypothetical protein -
BDL_RS04340 1067119..1067601 - 483 WP_020850286.1 DUF2778 domain-containing protein -
BDL_RS04345 1067671..1068570 - 900 WP_041188525.1 hypothetical protein -
BDL_RS04350 1069072..1069656 - 585 WP_020850011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1046786..1076030 29244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T29859 WP_006027262.1 NC_021877:1065274-1065570 [Burkholderia pseudomallei MSHR305]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T29859 NC_021877:1065274-1065570 [Burkholderia pseudomallei MSHR305]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT29859 WP_004202809.1 NC_021877:1065573-1065929 [Burkholderia pseudomallei MSHR305]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT29859 NC_021877:1065573-1065929 [Burkholderia pseudomallei MSHR305]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References