Detailed information of TA system TA029856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/ParE-CC2985
• Location: 72662..73211
• Replicon: plasmid RM1
• Accession: NC_021871
• Organism: Salmonella bongori N268-08

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: S5N4F3
• Locus tag: A464_RS22950
• Protein ID: WP_020842555.1
• Coordinates: 72662..72958 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: S5N4Z6
• Locus tag: A464_RS22955
• Protein ID: WP_020842556.1
• Coordinates: 72945..73211 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A464_RS25370	67822..68097	-	276	Protein_80	IS3 family transposase	-
A464_RS24515	68093..68293	+	201	Protein_81	transposase	-
A464_RS22925	68640..69170	-	531	WP_020842550.1	GNAT family N-acetyltransferase	-
A464_RS22930	69174..69443	-	270	WP_020842551.1	DUF1778 domain-containing protein	-
A464_RS22940	70293..71282	+	990	WP_077909641.1	RepB family plasmid replication initiator protein	-
A464_RS22945	71529..72314	-	786	WP_049823145.1	site-specific integrase	-
A464_RS25380	72428..72553	-	126	WP_138993539.1	transcriptional regulator	-
A464_RS22950	72662..72958	-	297	WP_020842555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A464_RS22955	72945..73211	-	267	WP_020842556.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A464_RS22960	73370..73713	+	344	Protein_89	IS3 family transposase	-
A464_RS22965	74814..75458	-	645	WP_020842560.1	hypothetical protein	-
A464_RS22970	75495..76091	-	597	WP_020842561.1	hypothetical protein	-
A464_RS22975	76856..77302	-	447	WP_020842563.1	lysozyme	-
A464_RS22980	77305..77619	-	315	WP_020842564.1	hypothetical protein	-
A464_RS22985	77739..78089	+	351	WP_020842565.1	winged helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..89986	89986

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11437.04 Da
• Isoelectric Point: 6.2068

>T29856 WP_020842555.1 NC_021871:c72958-72662 [Salmonella bongori N268-08]
VKTVKLTPKASQDLEGIWYYGDHHFGEGQADRYINQISCIFQVMSDHNIGTPRPELGEYIFALPVERHMLYFLQSDIEII
IIRILSQHQDAGRHLNWL

Nucleotide

• Length: 297 bp

>T29856 NC_021871:c72958-72662 [Salmonella bongori N268-08]
GTGAAAACCGTTAAACTAACACCTAAAGCCAGTCAGGATCTTGAAGGTATCTGGTATTACGGGGACCACCATTTCGGTGA
GGGACAAGCTGACAGATATATTAATCAAATCTCCTGCATTTTTCAGGTTATGAGTGATCATAATATCGGTACTCCCCGTC
CTGAACTGGGGGAATACATATTCGCATTACCCGTTGAACGGCATATGCTTTATTTTTTGCAGAGTGATATCGAAATTATT
ATTATCCGTATATTAAGTCAGCATCAGGATGCTGGTCGTCATCTCAACTGGCTGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9937.28 Da
• Isoelectric Point: 5.2410

>AT29856 WP_020842556.1 NC_021871:c73211-72945 [Salmonella bongori N268-08]
MARTMTVDLGVELREFIESLIESGDYRTQSEVIRESLRLLREKQAESRLQALRDLLAEGLSSGEPVAWEKDAFLKKVKAG
TRSAGENR

Nucleotide

• Length: 267 bp

>AT29856 NC_021871:c73211-72945 [Salmonella bongori N268-08]
ATGGCCAGAACAATGACTGTGGATCTCGGGGTTGAACTCCGGGAGTTTATAGAATCTCTCATAGAATCAGGCGATTATCG
TACACAGAGTGAAGTGATCCGCGAGTCACTTCGTCTCCTGCGTGAGAAGCAGGCAGAGTCACGTCTCCAGGCTCTGCGAG
ATTTACTGGCAGAAGGCCTGAGCAGCGGCGAACCAGTGGCGTGGGAAAAGGACGCGTTTCTGAAAAAAGTTAAAGCTGGT
ACGAGATCTGCCGGTGAAAACCGTTAA

Structures

Toxin

• AlphaFold DB: S5N4F3

Antitoxin

• AlphaFold DB: S5N4Z6