Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 60434..60959 Replicon plasmid RM1
Accession NC_021871
Organism Salmonella bongori N268-08

Toxin (Protein)


Gene name ccdB Uniprot ID S5NNW5
Locus tag A464_RS22880 Protein ID WP_020842535.1
Coordinates 60434..60739 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag A464_RS22885 Protein ID WP_000813642.1
Coordinates 60741..60959 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A464_RS22860 55444..56373 + 930 WP_020842527.1 Rpn family recombination-promoting nuclease/putative transposase -
A464_RS22865 56676..57756 - 1081 Protein_67 LD-carboxypeptidase -
A464_RS22870 58315..59256 + 942 WP_020842533.1 Rpn family recombination-promoting nuclease/putative transposase -
A464_RS22875 59407..60189 - 783 WP_020842534.1 site-specific integrase -
A464_RS24895 60227..60361 - 135 Protein_70 cytoplasmic protein -
A464_RS22880 60434..60739 - 306 WP_020842535.1 type II toxin-antitoxin system toxin CcdB Toxin
A464_RS22885 60741..60959 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
A464_RS22890 61630..61860 + 231 WP_020842536.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
A464_RS22895 61857..62285 + 429 WP_042917490.1 type II toxin-antitoxin system VapC family toxin -
A464_RS25360 62512..62757 - 246 WP_138993537.1 hypothetical protein -
A464_RS22905 63002..63781 - 780 WP_020842541.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..89986 89986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11607.41 Da        Isoelectric Point: 7.0105

>T29853 WP_020842535.1 NC_021871:c60739-60434 [Salmonella bongori N268-08]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSDRVPRDLYPVMHIGDESYRLLTTDMASVPATVIGEEV
ADLSLRENDIKNAINLMFRGV

Download         Length: 306 bp

>T29853 NC_021871:c60739-60434 [Salmonella bongori N268-08]
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGACAGGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGTCTTACCGCCTGCTGACCACGGATATGGCCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGGTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8328.19 Da        Isoelectric Point: 4.5358

>AT29853 WP_000813642.1 NC_021871:c60959-60741 [Salmonella bongori N268-08]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW

Download         Length: 219 bp

>AT29853 NC_021871:c60959-60741 [Salmonella bongori N268-08]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NNW5

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References