Detailed information of TA system TA029842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1569260..1570002
• Replicon: chromosome
• Accession: NC_021870
• Organism: Salmonella bongori N268-08

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: S5N833
• Locus tag: A464_RS07665
• Protein ID: WP_020844237.1
• Coordinates: 1569260..1569748 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: A464_RS07670
• Protein ID: WP_020844238.1
• Coordinates: 1569736..1570002 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A464_RS07645	1565056..1566564	-	1509	WP_020844233.1	FAD-dependent oxidoreductase	-
A464_RS07650	1566609..1567097	+	489	WP_020844234.1	MarR family winged helix-turn-helix transcriptional regulator	-
A464_RS07655	1567274..1568353	+	1080	WP_020844235.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
A464_RS07660	1568421..1568810	-	390	WP_015702869.1	RidA family protein	-
A464_RS07665	1569260..1569748	-	489	WP_020844237.1	GNAT family N-acetyltransferase	Toxin
A464_RS07670	1569736..1570002	-	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
A464_RS07675	1570117..1572192	-	2076	WP_020844239.1	glycogen debranching protein GlgX	-
A464_RS07680	1572235..1574763	-	2529	WP_020844240.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17749.50 Da
• Isoelectric Point: 9.5852

>T29842 WP_020844237.1 NC_021870:c1569748-1569260 [Salmonella bongori N268-08]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T29842 NC_021870:c1569748-1569260 [Salmonella bongori N268-08]
GTGGGAAAAGTAACCGCGCCTGCACCGTTATCCACGCTGCATAACCTGGCGGAATTCTGCTGCGGTGAAAGTCTGTTAGA
CGACTGGCTGCGGCAACGTGCGTTAAAAAACCAGGCGACTGGCGCATCCAGAACTTTTGTGGTGTGCAAAGCCGCCAGCC
ATCAGGTCGTTGGGTTTTATTCGCTGGCAACGGGCAGCGTTAATCACGCTGAAGCGACGGGCAGTTTGCGCCGCAATATG
CCCGATCCAATTCCGGTCATTATCCTGGCGCGTCTGGCTGTAGATGTGTCTTATCATGGAATCGGGCTGGGCGCGGATTT
ATTGCGCGATGCCATATTACGCGCGTATCGGGTGGCGGAAAATATCGGCGTTCGGGCGATGGTGGTGCAGGCGTTAACAG
AACAGGCTAAACGCTTCTATCTGCATCATGGTTTTCGGGAATCAGGTAAGCAAGAGAGGACGCTATTTCTTATCCTTCCG
GAAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT29842 WP_020844238.1 NC_021870:c1570002-1569736 [Salmonella bongori N268-08]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT29842 NC_021870:c1570002-1569736 [Salmonella bongori N268-08]
ATGAAATCAGGCGTTCAACTCAATATTCGGGCCAAAGAGTCACAGCGGGCGTTAATCGATACGGCGGCCGAGATTCTGCA
TAAATCACGAACCGACTTTATCCTTGAAATGGCTTGCCAGGCAGCCGAAAACGTTATTCTGGATCGCCGGGTATTTAACC
TTAACGATGATCAATACGCCGAGTTTGTTGAAATGCTTGATGCGCCTGTTGCTACAAATCCGGCGCTGGATAACTTACTG
GCGAGAAAACCACTGTGGGAAAAGTAA

Structures

Toxin

• AlphaFold DB: S5N833

Antitoxin

• AlphaFold DB: S5MPV7