Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 452022..452642 Replicon chromosome
Accession NC_021870
Organism Salmonella bongori N268-08

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A464_RS02055 Protein ID WP_001280991.1
Coordinates 452022..452240 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A464_RS02060 Protein ID WP_000344807.1
Coordinates 452268..452642 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A464_RS02020 447260..447829 + 570 WP_000779806.1 YbaY family lipoprotein -
A464_RS02025 447862..448251 - 390 WP_020842827.1 MGMT family protein -
A464_RS02030 448490..450040 - 1551 WP_020842828.1 EAL domain-containing protein -
A464_RS02035 450245..450505 + 261 WP_000801419.1 type B 50S ribosomal protein L31 -
A464_RS02040 450511..450651 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A464_RS02045 450704..451174 - 471 WP_000136180.1 YlaC family protein -
A464_RS02050 451292..451843 - 552 WP_020842829.1 maltose O-acetyltransferase -
A464_RS02055 452022..452240 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
A464_RS02060 452268..452642 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A464_RS02065 453138..456287 - 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
A464_RS02070 456310..457503 - 1194 WP_020842830.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T29841 WP_001280991.1 NC_021870:c452240-452022 [Salmonella bongori N268-08]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T29841 NC_021870:c452240-452022 [Salmonella bongori N268-08]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGATAACGAGTTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATTCCTTCTTCTGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT29841 WP_000344807.1 NC_021870:c452642-452268 [Salmonella bongori N268-08]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT29841 NC_021870:c452642-452268 [Salmonella bongori N268-08]
ATGGACGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
GAACCTTGAAGAAAGCAACCATGGTTGGGTTAACGATCCGACCTCAGCAGTCAATCTTCAGCTCAATGAACTGATCGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCACAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTTGTTAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References