Detailed information of TA system TA029840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 973455..974014
• Replicon: chromosome
• Accession: NC_021848
• Organism: Vibrio parahaemolyticus O1:K33 str. CDC K4557

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HK81_RS12460
• Protein ID: WP_020838852.1
• Coordinates: 973455..973733 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HK81_RS12465
• Protein ID: WP_020838853.1
• Coordinates: 973730..974014 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK81_RS12425	968681..968965	+	285	WP_020838846.1	hypothetical protein	-
HK81_RS24215	968988..969080	+	93	WP_074534777.1	DUF3265 domain-containing protein	-
HK81_RS12430	969108..969554	+	447	WP_020838847.1	hypothetical protein	-
HK81_RS24220	969578..969667	+	90	Protein_880	DUF3265 domain-containing protein	-
HK81_RS12435	969699..970127	+	429	WP_020838848.1	ester cyclase	-
HK81_RS24230	970706..970783	+	78	WP_074534802.1	DUF3265 domain-containing protein	-
HK81_RS23395	971370..971753	+	384	WP_020838849.1	hypothetical protein	-
HK81_RS12450	971906..972190	+	285	WP_020838850.1	nucleotide pyrophosphohydrolase	-
HK81_RS12455	972343..973314	+	972	WP_020838851.1	phosphotransferase	-
HK81_RS12460	973455..973733	-	279	WP_020838852.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HK81_RS12465	973730..974014	-	285	WP_020838853.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HK81_RS24245	974094..974183	+	90	WP_074534800.1	DUF3265 domain-containing protein	-
HK81_RS12470	974233..974640	+	408	WP_020838854.1	OsmC family protein	-
HK81_RS12475	974792..975337	+	546	WP_020838855.1	GNAT family N-acetyltransferase	-
HK81_RS12480	975460..975744	+	285	WP_020838856.1	nucleotide pyrophosphohydrolase	-
HK81_RS25940	975891..976235	+	345	WP_020838857.1	hypothetical protein	-
HK81_RS24255	976232..976351	+	120	WP_154218809.1	DUF3265 domain-containing protein	-
HK81_RS12490	976391..976795	+	405	WP_020838858.1	DUF4019 domain-containing protein	-
HK81_RS12495	977248..977721	+	474	WP_199873221.1	hypothetical protein	-
HK81_RS12500	977727..978194	+	468	WP_136678154.1	hypothetical protein	-
HK81_RS12505	978303..978809	+	507	WP_029559408.1	AAA family ATPase	-
HK81_RS24260	978812..978928	+	117	WP_162142208.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611	839620..1233018	393398
	-	inside	Integron	-	-	923397..1013491	90094

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10921.66 Da
• Isoelectric Point: 4.3430

>T29840 WP_020838852.1 NC_021848:c973733-973455 [Vibrio parahaemolyticus O1:K33 str. CDC_K4557]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGVRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T29840 NC_021848:c973733-973455 [Vibrio parahaemolyticus O1:K33 str. CDC_K4557]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGCGAAAAAATCTTTGAGTTTCTCTATGATTTCAACCCTGATGCTGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTAGAGCAACCTCTAATGGGTGTACAGCGAGATGGTG
TTCGTGGACGGTTGCTCATTATTCCTGAGATTTCGATGATCGTCTCATATTGGGTCGAAGGCGATATCATCCGAATTATG
CGCGTACTACACCAGAAACAAAAATTCCCTATGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11039.37 Da
• Isoelectric Point: 9.2167

>AT29840 WP_020838853.1 NC_021848:c974014-973730 [Vibrio parahaemolyticus O1:K33 str. CDC_K4557]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT29840 NC_021848:c974014-973730 [Vibrio parahaemolyticus O1:K33 str. CDC_K4557]
ATGGACACTAGAATTCAATTTCGTGTTGATGAGGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGCAC
ATTAAGTGATGCTTGCCGTGAACTAACTGAACAACTCGCTGACCAACAACGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTTTTCGTTGAACACCAAACTGCTAAATCTCGA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA