Detailed information of TA system TA029839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2326491..2327056
• Replicon: chromosome
• Accession: NC_021847
• Organism: Vibrio parahaemolyticus O1:Kuk str. FDA R31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A916ASF8
• Locus tag: HK86_RS10880
• Protein ID: WP_005445239.1
• Coordinates: 2326491..2326778 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: HK86_RS10885
• Protein ID: WP_000086647.1
• Coordinates: 2326775..2327056 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK86_RS24950	2321951..2322043	-	93	WP_079855392.1	DUF3265 domain-containing protein	-
HK86_RS10860	2322074..2322652	-	579	WP_020840850.1	hypothetical protein	-
HK86_RS24955	2324195..2324287	-	93	WP_080212138.1	DUF3265 domain-containing protein	-
HK86_RS10865	2324302..2325048	-	747	WP_020840851.1	hypothetical protein	-
HK86_RS10870	2325191..2325769	-	579	WP_041170655.1	hypothetical protein	-
HK86_RS26225	2325787..2325915	-	129	WP_139148886.1	DUF3265 domain-containing protein	-
HK86_RS24965	2326371..2326463	-	93	WP_079881687.1	DUF3265 domain-containing protein	-
HK86_RS10880	2326491..2326778	-	288	WP_005445239.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HK86_RS10885	2326775..2327056	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HK86_RS24970	2327147..2327257	-	111	WP_162471500.1	DUF3265 domain-containing protein	-
HK86_RS10890	2327254..2327787	-	534	WP_020840854.1	hypothetical protein	-
HK86_RS10895	2327942..2328520	-	579	WP_041170655.1	hypothetical protein	-
HK86_RS24975	2329103..2329213	-	111	WP_079857913.1	DUF3265 domain-containing protein	-
HK86_RS10900	2329835..2330797	+	963	WP_041170703.1	integron integrase	-
HK86_RS10905	2330848..2331321	-	474	WP_020840857.1	DUF2947 domain-containing protein	-
HK86_RS10910	2331335..2331922	-	588	WP_020840858.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2200026..2464903	264877
	-	inside	Integron	-	-	2272433..2330797	58364

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11031.70 Da
• Isoelectric Point: 5.1098

>T29839 WP_005445239.1 NC_021847:c2326778-2326491 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T29839 NC_021847:c2326778-2326491 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAACCCACCTGC
AGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCACACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATCCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT29839 WP_000086647.1 NC_021847:c2327056-2326775 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT29839 NC_021847:c2327056-2326775 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0