Detailed information of TA system TA029837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2236190..2236718
• Replicon: chromosome
• Accession: NC_021847
• Organism: Vibrio parahaemolyticus O1:Kuk str. FDA R31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X8YM79
• Locus tag: HK86_RS10300
• Protein ID: WP_020840746.1
• Coordinates: 2236428..2236718 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: HK86_RS10295
• Protein ID: WP_005377003.1
• Coordinates: 2236190..2236438 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK86_RS10270	2231357..2233063	-	1707	WP_041170648.1	autotransporter assembly complex protein TamA	-
HK86_RS10280	2233511..2234607	+	1097	WP_144077960.1	IS3 family transposase	-
HK86_RS10285	2234876..2235322	-	447	WP_020840744.1	GNAT family N-acetyltransferase	-
HK86_RS10290	2235459..2235995	-	537	WP_020840745.1	nucleotidyltransferase family protein	-
HK86_RS10295	2236190..2236438	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HK86_RS10300	2236428..2236718	+	291	WP_020840746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HK86_RS10305	2236844..2237296	-	453	WP_043048411.1	PH domain-containing protein	-
HK86_RS10310	2237433..2237933	-	501	WP_020840748.1	GNAT family N-acetyltransferase	-
HK86_RS26100	2238008..2238175	-	168	WP_089190283.1	DUF3265 domain-containing protein	-
HK86_RS26105	2238448..2238558	-	111	WP_108064550.1	DUF3265 domain-containing protein	-
HK86_RS10325	2239061..2239552	-	492	WP_139148890.1	hypothetical protein	-
HK86_RS10330	2239811..2240851	+	1041	WP_020840752.1	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2200026..2464903	264877
	-	flank	IS/Tn	-	-	2239811..2240851	1040
	-	inside	Integron	-	-	2233756..2250359	16603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11288.28 Da
• Isoelectric Point: 10.5932

>T29837 WP_020840746.1 NC_021847:2236428-2236718 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERNDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T29837 NC_021847:2236428-2236718 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCTGTCGGGAAA
CGCGAACGTAACGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT29837 WP_005377003.1 NC_021847:2236190-2236438 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT29837 NC_021847:2236190-2236438 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTACTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A7X8YM79

Antitoxin

• AlphaFold DB: A0A347UR02