Detailed information of TA system TA029836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 10590..11112
• Replicon: plasmid pSEEH1578_02
• Accession: NC_021841
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: SEEH1578_RS23865
• Protein ID: WP_000220561.1
• Coordinates: 10590..10871 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: SEEH1578_RS23870
• Protein ID: WP_000121743.1
• Coordinates: 10861..11112 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEH1578_RS23820	5861..6208	-	348	WP_000681613.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEH1578_RS23825	6205..6453	-	249	WP_000520549.1	type II toxin-antitoxin system HicA family toxin	-
SEEH1578_RS23830	6758..7108	-	351	WP_000854259.1	hypothetical protein	-
SEEH1578_RS23835	7199..7498	-	300	WP_000650309.1	hypothetical protein	-
SEEH1578_RS23840	7952..8179	-	228	WP_000801440.1	hypothetical protein	-
SEEH1578_RS23845	8166..8417	-	252	WP_001230707.1	hypothetical protein	-
SEEH1578_RS23850	8414..8956	-	543	WP_001083906.1	hypothetical protein	-
SEEH1578_RS23855	9061..9576	-	516	WP_001025395.1	J domain-containing protein	-
SEEH1578_RS23860	10216..10566	-	351	WP_000312755.1	hypothetical protein	-
SEEH1578_RS23865	10590..10871	-	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SEEH1578_RS23870	10861..11112	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
SEEH1578_RS23875	12478..13485	+	1008	WP_000243325.1	replication initiation protein	-
SEEH1578_RS23880	13551..13955	+	405	WP_000654312.1	hypothetical protein	-
SEEH1578_RS23885	14091..14618	+	528	WP_000577047.1	DUF2726 domain-containing protein	-
SEEH1578_RS23895	15190..15441	-	252	WP_000905714.1	hypothetical protein	-
SEEH1578_RS23900	15478..15780	-	303	WP_001062963.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..35297	35297

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T29836 WP_000220561.1 NC_021841:c10871-10590 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T29836 NC_021841:c10871-10590 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT29836 WP_000121743.1 NC_021841:c11112-10861 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT29836 NC_021841:c11112-10861 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
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Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301