Detailed information of TA system TA029835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/MqsA(antitoxin)
• Location: 7952..8417
• Replicon: plasmid pSEEH1578_02
• Accession: NC_021841
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: U9ZUY2
• Locus tag: SEEH1578_RS23845
• Protein ID: WP_001230707.1
• Coordinates: 8166..8417 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: M7CCF8
• Locus tag: SEEH1578_RS23840
• Protein ID: WP_000801440.1
• Coordinates: 7952..8179 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEH1578_RS23800	3182..3415	-	234	WP_000120384.1	EexN family lipoprotein	-
SEEH1578_RS23805	3420..3686	-	267	WP_000134734.1	hypothetical protein	-
SEEH1578_RS23810	3763..4992	-	1230	WP_001329504.1	relaxase/mobilization nuclease domain-containing protein	-
SEEH1578_RS23815	4996..5499	-	504	WP_000781816.1	hypothetical protein	-
SEEH1578_RS23820	5861..6208	-	348	WP_000681613.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEH1578_RS23825	6205..6453	-	249	WP_000520549.1	type II toxin-antitoxin system HicA family toxin	-
SEEH1578_RS23830	6758..7108	-	351	WP_000854259.1	hypothetical protein	-
SEEH1578_RS23835	7199..7498	-	300	WP_000650309.1	hypothetical protein	-
SEEH1578_RS23840	7952..8179	-	228	WP_000801440.1	hypothetical protein	Antitoxin
SEEH1578_RS23845	8166..8417	-	252	WP_001230707.1	hypothetical protein	Toxin
SEEH1578_RS23850	8414..8956	-	543	WP_001083906.1	hypothetical protein	-
SEEH1578_RS23855	9061..9576	-	516	WP_001025395.1	J domain-containing protein	-
SEEH1578_RS23860	10216..10566	-	351	WP_000312755.1	hypothetical protein	-
SEEH1578_RS23865	10590..10871	-	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SEEH1578_RS23870	10861..11112	-	252	WP_000121743.1	plasmid stabilization protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..35297	35297

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-99)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>T29835 WP_001230707.1 NC_021841:c8417-8166 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>T29835 NC_021841:c8417-8166 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTT

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT29835 WP_000801440.1 NC_021841:c8179-7952 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT29835 NC_021841:c8179-7952 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: U9ZUY2

Antitoxin

• AlphaFold DB: A0A5Y6U8W9