Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5861..6453 Replicon plasmid pSEEH1578_02
Accession NC_021841
Organism Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag SEEH1578_RS23825 Protein ID WP_000520549.1
Coordinates 6205..6453 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag SEEH1578_RS23820 Protein ID WP_000681613.1
Coordinates 5861..6208 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEH1578_RS23790 1862..2134 - 273 WP_001328551.1 TrbC/VirB2 family protein -
SEEH1578_RS25735 2202..2822 - 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
SEEH1578_RS23800 3182..3415 - 234 WP_000120384.1 EexN family lipoprotein -
SEEH1578_RS23805 3420..3686 - 267 WP_000134734.1 hypothetical protein -
SEEH1578_RS23810 3763..4992 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
SEEH1578_RS23815 4996..5499 - 504 WP_000781816.1 hypothetical protein -
SEEH1578_RS23820 5861..6208 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SEEH1578_RS23825 6205..6453 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
SEEH1578_RS23830 6758..7108 - 351 WP_000854259.1 hypothetical protein -
SEEH1578_RS23835 7199..7498 - 300 WP_000650309.1 hypothetical protein -
SEEH1578_RS23840 7952..8179 - 228 WP_000801440.1 hypothetical protein -
SEEH1578_RS23845 8166..8417 - 252 WP_001230707.1 hypothetical protein -
SEEH1578_RS23850 8414..8956 - 543 WP_001083906.1 hypothetical protein -
SEEH1578_RS23855 9061..9576 - 516 WP_001025395.1 J domain-containing protein -
SEEH1578_RS23860 10216..10566 - 351 WP_000312755.1 hypothetical protein -
SEEH1578_RS23865 10590..10871 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
SEEH1578_RS23870 10861..11112 - 252 WP_000121743.1 plasmid stabilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35297 35297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T29834 WP_000520549.1 NC_021841:c6453-6205 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T29834 NC_021841:c6453-6205 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTT

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT29834 WP_000681613.1 NC_021841:c6208-5861 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT29834 NC_021841:c6208-5861 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References