Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 86444..88067 Replicon plasmid unnamed
Accession NC_021819
Organism Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050

Toxin (Protein)


Gene name hipA Uniprot ID A0A7G9A813
Locus tag CFSAN002050_RS25490 Protein ID WP_020833823.1
Coordinates 86444..87769 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A411GQR5
Locus tag CFSAN002050_RS25495 Protein ID WP_024143029.1
Coordinates 87774..88067 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFSAN002050_RS25460 82431..83288 - 858 WP_020833820.1 HNH endonuclease -
CFSAN002050_RS25465 83304..83612 - 309 WP_001224686.1 hypothetical protein -
CFSAN002050_RS25470 84160..84585 - 426 WP_020833821.1 hypothetical protein -
CFSAN002050_RS25475 84837..85652 - 816 WP_024143028.1 HNH endonuclease -
CFSAN002050_RS25480 85665..86075 - 411 WP_000985911.1 hypothetical protein -
CFSAN002050_RS25485 86177..86383 - 207 WP_000134171.1 hypothetical protein -
CFSAN002050_RS25490 86444..87769 - 1326 WP_020833823.1 type II toxin-antitoxin system HipA family toxin Toxin
CFSAN002050_RS25495 87774..88067 - 294 WP_024143029.1 helix-turn-helix transcriptional regulator Antitoxin
CFSAN002050_RS25500 88470..89858 - 1389 WP_008786875.1 hypothetical protein -
CFSAN002050_RS25505 89863..90360 - 498 WP_008786874.1 membrane protein -
CFSAN002050_RS25510 90562..91209 - 648 WP_008786873.1 hypothetical protein -
CFSAN002050_RS25515 92165..92557 - 393 WP_020833826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-9 - 1..122863 122863
- flank IS/Tn - - 80902..81942 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-70)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50230.15 Da        Isoelectric Point: 6.1424

>T29824 WP_020833823.1 NC_021819:c87769-86444 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPEWSADEQGRPLSLSIPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAEHDKAQFFMAQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T29824 NC_021819:c87769-86444 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
ATGAGCCGTAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTTGA
CAGCTTACAATACCTTCCTGAATGGAGTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCATTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGACGAACCCACAGATTTATATTCCGTGAAGTATCACCCTCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCGATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAAGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGCGCTGAGC
ATGACAAAGCGCAGTTTTTTATGGCGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGATATCACCTAACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGACATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCAGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10846.21 Da        Isoelectric Point: 10.3134

>AT29824 WP_024143029.1 NC_021819:c88067-87774 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
INNEYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSVLGVKISFSSTATSSDSK
QTEETLKSNSPARQEKW

Download         Length: 294 bp

>AT29824 NC_021819:c88067-87774 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
ATCAATAATGAATACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACACAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCGTCCTGGGTGTAAAAATCAGCTTCTCCTCGACGGCCACCTCTTCAGATAGTAAG
CAGACGGAAGAAACGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G9A813

Antitoxin

Source ID Structure
AlphaFold DB A0A411GQR5

References