Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 56169..56695 Replicon plasmid unnamed
Accession NC_021819
Organism Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CFSAN002050_RS25330 Protein ID WP_000323025.1
Coordinates 56169..56456 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CFSAN002050_RS25335 Protein ID WP_000534858.1
Coordinates 56456..56695 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFSAN002050_RS25305 51351..52676 - 1326 WP_020833804.1 type II toxin-antitoxin system HipA family toxin -
CFSAN002050_RS25310 52681..52974 - 294 WP_024143021.1 helix-turn-helix transcriptional regulator -
CFSAN002050_RS25315 53375..54727 - 1353 WP_049827791.1 hypothetical protein -
CFSAN002050_RS25325 54809..56049 + 1241 Protein_56 IS3 family transposase -
CFSAN002050_RS25330 56169..56456 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CFSAN002050_RS25335 56456..56695 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CFSAN002050_RS25340 56958..57881 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
CFSAN002050_RS25345 58081..58653 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
CFSAN002050_RS25350 59129..60367 - 1239 WP_003030308.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-9 - 1..122863 122863
- inside IScluster/Tn - - 55162..62883 7721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T29823 WP_000323025.1 NC_021819:c56456-56169 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T29823 NC_021819:c56456-56169 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT29823 WP_000534858.1 NC_021819:c56695-56456 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT29823 NC_021819:c56695-56456 [Salmonella enterica subsp. enterica serovar Cubana str. CFSAN002050]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References