Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 98149..98696 Replicon plasmid pCFSAN002069_01
Accession NC_021813
Organism Salmonella enterica subsp. enterica serovar Heidelberg str.

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CFSAN002069_RS00505 Protein ID WP_000969996.1
Coordinates 98149..98430 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CFSAN002069_RS00510 Protein ID WP_000079941.1
Coordinates 98427..98696 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFSAN002069_RS00490 94431..95291 - 861 WP_000344784.1 TniB family NTP-binding protein -
CFSAN002069_RS00495 95294..96943 - 1650 WP_000896475.1 DDE-type integrase/transposase/recombinase -
CFSAN002069_RS26550 96899..97024 + 126 Protein_105 MerR family transcriptional regulator -
CFSAN002069_RS00500 97261..98109 - 849 WP_001057996.1 3'-5' exonuclease -
CFSAN002069_RS00505 98149..98430 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFSAN002069_RS00510 98427..98696 - 270 WP_000079941.1 hypothetical protein Antitoxin
CFSAN002069_RS00515 99605..100636 - 1032 WP_000907875.1 replication initiation protein -
CFSAN002069_RS24090 101609..101872 + 264 WP_001324596.1 ash family protein -
CFSAN002069_RS00530 101790..102077 + 288 WP_000074849.1 conjugal transfer protein TraA -
CFSAN002069_RS00535 102519..103052 + 534 WP_001303319.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110363 110363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T29804 WP_000969996.1 NC_021813:c98430-98149 [Salmonella enterica subsp. enterica serovar Heidelberg str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T29804 NC_021813:c98430-98149 [Salmonella enterica subsp. enterica serovar Heidelberg str.]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Antitoxin


Download         Length: 90 a.a.        Molecular weight: 13263.91 Da        Isoelectric Point: 5.5500

>AT29804 WP_000079941.1 NC_021813:c98696-98427 [Salmonella enterica subsp. enterica serovar Heidelberg str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Download         Length: 270 bp

>AT29804 NC_021813:c98696-98427 [Salmonella enterica subsp. enterica serovar Heidelberg str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References