Detailed information of TA system TA029787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1590756..1591368
• Replicon: chromosome
• Accession: NC_021807
• Organism: Streptococcus pyogenes HSC5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L897_RS08045
• Protein ID: WP_002994716.1
• Coordinates: 1591033..1591368 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: L897_RS08040
• Protein ID: WP_002988079.1
• Coordinates: 1590756..1591043 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L897_RS08015	1585948..1586931	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
L897_RS08020	1586935..1587864	-	930	WP_020837785.1	tagatose-6-phosphate kinase	-
L897_RS08025	1587910..1588425	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
L897_RS08030	1588460..1588888	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
L897_RS08035	1589333..1590106	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
L897_RS08040	1590756..1591043	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
L897_RS08045	1591033..1591368	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L897_RS09735	1591520..1591990	+	471	WP_021733374.1	site-specific integrase	-
L897_RS09740	1591953..1592501	+	549	WP_136115776.1	site-specific integrase	-
L897_RS08055	1592621..1593013	-	393	WP_002982716.1	30S ribosomal protein S9	-
L897_RS08060	1593034..1593480	-	447	WP_002982710.1	50S ribosomal protein L13	-
L897_RS08065	1593698..1593904	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
L897_RS08070	1593901..1594407	-	507	WP_002988070.1	hypothetical protein	-
L897_RS08075	1594543..1595403	-	861	WP_002982687.1	DegV family protein	-
L897_RS08080	1595500..1596018	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T29787 WP_002994716.1 NC_021807:1591033-1591368 [Streptococcus pyogenes HSC5]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T29787 NC_021807:1591033-1591368 [Streptococcus pyogenes HSC5]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT29787 WP_002988079.1 NC_021807:1590756-1591043 [Streptococcus pyogenes HSC5]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT29787 NC_021807:1590756-1591043 [Streptococcus pyogenes HSC5]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94