Detailed information of TA system TA029777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 4854267..4854832
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: M495_RS22685
• Protein ID: WP_020837304.1
• Coordinates: 4854554..4854832 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A380ARC2
• Locus tag: M495_RS22680
• Protein ID: WP_020837302.1
• Coordinates: 4854267..4854536 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS22665	4850480..4851697	-	1218	WP_020837295.1	aspartate aminotransferase family protein	-
M495_RS22670	4851829..4852404	-	576	WP_020837297.1	aminodeoxychorismate synthase component II	-
M495_RS22675	4852515..4854041	-	1527	WP_020837300.1	DUF853 family protein	-
M495_RS22680	4854267..4854536	+	270	WP_020837302.1	hypothetical protein	Antitoxin
M495_RS22685	4854554..4854832	+	279	WP_020837304.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M495_RS22690	4854833..4855558	-	726	WP_020837306.1	two-component system response regulator BtsR	-
M495_RS22695	4855558..4857242	-	1685	Protein_4488	sensor histidine kinase	-
M495_RS22700	4857404..4857973	-	570	WP_020837308.1	peptidylprolyl isomerase A	-
M495_RS22705	4858331..4858669	+	339	WP_041415733.1	PTS lactose/cellobiose transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10374.00 Da
• Isoelectric Point: 9.8344

>T29777 WP_020837304.1 NC_021741:4854554-4854832 [Serratia liquefaciens ATCC 27592]
VKLKWTDPTIADRMAIYDYLASKNPIAAAEIDALISAAASQLSRNPSSGKVGRVSGTREWVIHHFYLLIYEVKNDLLIIL
AVVHSRRQWPKD

Nucleotide

• Length: 279 bp

>T29777 NC_021741:4854554-4854832 [Serratia liquefaciens ATCC 27592]
GTGAAGCTAAAGTGGACGGATCCCACAATTGCTGACCGTATGGCAATTTATGACTATCTTGCGTCAAAGAACCCGATAGC
TGCCGCAGAGATTGATGCTTTGATTTCTGCGGCGGCAAGCCAACTATCCCGAAACCCATCAAGTGGCAAAGTGGGCCGGG
TTTCAGGTACACGTGAATGGGTCATTCATCATTTTTACCTACTGATTTATGAAGTAAAAAATGACCTTCTTATTATTTTG
GCAGTCGTACATTCCCGCCGGCAATGGCCAAAGGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.64 Da
• Isoelectric Point: 5.2281

>AT29777 WP_020837302.1 NC_021741:4854267-4854536 [Serratia liquefaciens ATCC 27592]
MSESTVVIRVDDELKIAFASAAKAADRTASQLLRDFMRDFVSRQSQQKEYEQWLQEKVDLSRKALQEGRVVDNEDVEAYF
AERRAKSMR

Nucleotide

• Length: 270 bp

>AT29777 NC_021741:4854267-4854536 [Serratia liquefaciens ATCC 27592]
ATGTCTGAATCTACCGTGGTTATCCGCGTGGATGACGAGTTAAAAATAGCTTTTGCCAGCGCGGCCAAAGCAGCGGATCG
AACGGCATCTCAGCTTTTACGCGATTTCATGCGAGATTTTGTCAGTCGACAATCGCAGCAAAAAGAGTATGAACAGTGGT
TGCAGGAGAAGGTCGATTTAAGCCGAAAAGCGCTCCAGGAAGGAAGAGTGGTTGATAACGAGGACGTTGAGGCTTATTTC
GCCGAGCGCAGGGCAAAATCAATGCGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380ARC2