Detailed information of TA system TA029775

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4255893..4256562
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M495_RS19915
• Protein ID: WP_020828475.1
• Coordinates: 4255893..4256315 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: M495_RS19920
• Protein ID: WP_020828476.1
• Coordinates: 4256296..4256562 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS19895	4251779..4252297	+	519	WP_020828471.1	flavodoxin FldB	-
M495_RS19900	4252334..4253698	-	1365	WP_020828472.1	cell envelope integrity protein CreD	-
M495_RS19905	4253783..4255201	-	1419	WP_020828473.1	two-component system sensor histidine kinase CreC	-
M495_RS19910	4255198..4255893	-	696	WP_020828474.1	two-component system response regulator CreB	-
M495_RS19915	4255893..4256315	-	423	WP_020828475.1	protein YgfX	Toxin
M495_RS19920	4256296..4256562	-	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
M495_RS19925	4256885..4257871	+	987	WP_020828477.1	tRNA-modifying protein YgfZ	-
M495_RS19930	4257929..4258426	-	498	WP_020828478.1	DUF2165 domain-containing protein	-
M495_RS19935	4258590..4259264	-	675	WP_020828479.1	hemolysin III family protein	-
M495_RS19940	4259448..4260056	+	609	WP_020828480.1	HD domain-containing protein	-
M495_RS19945	4260097..4261421	-	1325	Protein_3940	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16577.54 Da
• Isoelectric Point: 10.6957

>T29775 WP_020828475.1 NC_021741:c4256315-4255893 [Serratia liquefaciens ATCC 27592]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLVKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T29775 NC_021741:c4256315-4255893 [Serratia liquefaciens ATCC 27592]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCGGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGTAGCCAAAAACGCATTGCGTCACGTCAGGGGGAGTTGCGCCTGCTGGAGAACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGTCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCCTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCGCCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT29775 WP_020828476.1 NC_021741:c4256562-4256296 [Serratia liquefaciens ATCC 27592]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT29775 NC_021741:c4256562-4256296 [Serratia liquefaciens ATCC 27592]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9