29772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3835293..3835945 Replicon chromosome
Accession NC_021741
Organism Serratia liquefaciens ATCC 27592

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YFT9
Locus tag M495_RS17955 Protein ID WP_020828096.1
Coordinates 3835293..3835679 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YGI8
Locus tag M495_RS17960 Protein ID WP_020828097.1
Coordinates 3835682..3835945 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M495_RS17940 3831758..3833188 + 1431 WP_020828093.1 MFS transporter -
M495_RS17945 3833188..3834570 + 1383 WP_020828094.1 two-component system sensor histidine kinase BaeS -
M495_RS17950 3834570..3835286 + 717 WP_020828095.1 two-component system response regulator BaeR -
M495_RS17955 3835293..3835679 - 387 WP_020828096.1 type II toxin-antitoxin system VapC family toxin Toxin
M495_RS17960 3835682..3835945 - 264 WP_020828097.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M495_RS17965 3836297..3836635 + 339 WP_020828098.1 YegP family protein -
M495_RS17970 3836813..3838165 + 1353 WP_041414820.1 tRNA 5-hydroxyuridine modification protein YegQ -
M495_RS17975 3838638..3839555 + 918 WP_020828101.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14093.28 Da        Isoelectric Point: 7.8799

>T29772 WP_020828096.1 NC_021741:c3835679-3835293 [Serratia liquefaciens ATCC 27592]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Download         Length: 387 bp

>T29772 NC_021741:c3835679-3835293 [Serratia liquefaciens ATCC 27592]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCATTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10091.38 Da        Isoelectric Point: 5.8701

>AT29772 WP_020828097.1 NC_021741:c3835945-3835682 [Serratia liquefaciens ATCC 27592]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Download         Length: 264 bp

>AT29772 NC_021741:c3835945-3835682 [Serratia liquefaciens ATCC 27592]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YFT9

Antitoxin

Source ID Structure
AlphaFold DB A0A379YGI8

References