Detailed information of TA system TA029771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3145140..3145765
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: M495_RS14785
• Protein ID: WP_020827484.1
• Coordinates: 3145140..3145322 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: M495_RS14790
• Protein ID: WP_020827485.1
• Coordinates: 3145352..3145765 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS14780	3141002..3144973	+	3972	WP_041414691.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
M495_RS14785	3145140..3145322	+	183	WP_020827484.1	type II toxin-antitoxin system HicA family toxin	Toxin
M495_RS14790	3145352..3145765	+	414	WP_020827485.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M495_RS14795	3145797..3146549	-	753	WP_020827486.1	L-cystine ABC transporter ATP-binding protein YecC	-
M495_RS14800	3146553..3147215	-	663	WP_020827487.1	cystine ABC transporter permease	-
M495_RS14805	3147215..3148015	-	801	WP_020827488.1	cystine ABC transporter substrate-binding protein	-
M495_RS14810	3148130..3149122	-	993	WP_020827489.1	D-cysteine desulfhydrase	-
M495_RS14815	3149250..3149759	-	510	WP_041414695.1	flagella biosynthesis regulatory protein FliZ	-
M495_RS14820	3149818..3150540	-	723	WP_020827491.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6796.97 Da
• Isoelectric Point: 10.9305

>T29771 WP_020827484.1 NC_021741:3145140-3145322 [Serratia liquefaciens ATCC 27592]
VRSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T29771 NC_021741:3145140-3145322 [Serratia liquefaciens ATCC 27592]
GTGAGAAGTTCAGAACTGATCGGGCTGTTAGAACAGGAAGGTTGGGTTTTAACGCGGATCAAGGGAAGCCACCATCAGTT
TAAGCACCCGAACTCCCGTCTGGTGATCACCGTTCCACATCCGCGAAAGGATCTGAAAGCGGGGACGCTGCGCCAAATCA
TGAAAGATGCCGGATTGTGCTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15094.74 Da
• Isoelectric Point: 4.6730

>AT29771 WP_020827485.1 NC_021741:3145352-3145765 [Serratia liquefaciens ATCC 27592]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFEDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQDNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT29771 NC_021741:3145352-3145765 [Serratia liquefaciens ATCC 27592]
ATGTTCTACCCTGCTTATGTACATTCTGAACCGGACGGCAGCGCCAGCGGCTTCTTTCCCGATGTGCCAGGCTGCTATTT
TGCCGGCGATACCCTGGACAGAGCCTTTGAAGACGCCAGAAGTGCGCTGGACGCCCATTTCGAATTCTTGAGCGAAGACA
ATCAGCCCATTCCTGGCCCACAGGCCGTGACCTTTCATCTGGCACAGGATAACGACAGTCTGAATGGCGGACAGTGGTTG
TTGGTCAATATTAATATGGATAAGTTTGATGGTCGGGCGGAGCGTATCAATATTACCTTGCCGCACCGTCTGCTGAACCG
CATAGATTCTCTGGTGCAGCAGCATCCCGGTTACGGTAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGCAATGAATTAT
TGAAAGCCGGGTAG