Detailed information of TA system TA029762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1046154..1046781
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: M495_RS04795
• Protein ID: WP_197821222.1
• Coordinates: 1046154..1046375 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: A0A379ZYL8
• Locus tag: M495_RS04800
• Protein ID: WP_020825515.1
• Coordinates: 1046413..1046781 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS04780	1041711..1043054	-	1344	WP_020825511.1	NCS2 family permease	-
M495_RS04785	1043219..1045006	-	1788	WP_020825512.1	adenine deaminase	-
M495_RS04790	1045145..1046077	+	933	WP_020825513.1	LysR family transcriptional regulator	-
M495_RS04795	1046154..1046375	-	222	WP_197821222.1	hemolysin expression modulator Hha	Toxin
M495_RS04800	1046413..1046781	-	369	WP_020825515.1	Hha toxicity modulator TomB	Antitoxin
M495_RS04805	1046944..1047270	-	327	WP_041415232.1	hypothetical protein	-
M495_RS25740	1047600..1047746	+	147	WP_020825517.1	hypothetical protein	-
M495_RS04810	1047743..1048465	+	723	WP_020825518.1	ABC transporter ATP-binding protein	-
M495_RS04815	1048452..1049309	+	858	WP_041414279.1	metal ABC transporter permease	-
M495_RS04820	1049335..1050213	+	879	WP_020825520.1	metal ABC transporter substrate-binding protein	-
M495_RS04825	1050326..1050466	-	141	WP_012005563.1	type B 50S ribosomal protein L36	-
M495_RS04830	1050479..1050733	-	255	WP_020825521.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1037790..1047297	9507

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (14-70)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8727.21 Da
• Isoelectric Point: 7.9877

>T29762 WP_197821222.1 NC_021741:c1046375-1046154 [Serratia liquefaciens ATCC 27592]
ITPKVIMTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 222 bp

>T29762 NC_021741:c1046375-1046154 [Serratia liquefaciens ATCC 27592]
ATAACACCAAAGGTTATCATGACTAAAACTGATTATCTGATGCGTTTACGTAAATGCACCACTATTGACACCCTTGAACG
CGTTATTGAAAAAAATAAGTATGAGCTTTCGGATGACGAATTGGAGCTGTTTTACTCTGCAGCTGACCACCGTCTGGCTG
AGCTCACCATGAATAAGCTCTACGATAAAATCCCAACGGCCGTTTGGAAGTTCGTACGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14189.89 Da
• Isoelectric Point: 4.5140

>AT29762 WP_020825515.1 NC_021741:c1046781-1046413 [Serratia liquefaciens ATCC 27592]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKS

Nucleotide

• Length: 369 bp

>AT29762 NC_021741:c1046781-1046413 [Serratia liquefaciens ATCC 27592]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATAGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGACCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAGGAATATCTC
GATGATACCTACACGTTGTTCAGCAGTTACGGTATCAATGATTCCGATCTGCGTCGCTGGCAAAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAATCTTAG

Structures

Antitoxin

• AlphaFold DB: A0A379ZYL8