Detailed information of TA system TA029761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 845547..846106
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: M495_RS03875
• Protein ID: WP_020825340.1
• Coordinates: 845547..845840 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: M495_RS03880
• Protein ID: WP_020825341.1
• Coordinates: 845828..846106 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS03855	840594..841544	-	951	WP_020825336.1	acetyltransferase	-
M495_RS03860	841541..843286	-	1746	WP_020825337.1	aerobactin synthase IucA	-
M495_RS03865	843424..844647	+	1224	WP_041414246.1	MFS transporter	-
M495_RS03870	844653..845537	+	885	WP_041414248.1	siderophore-interacting protein	-
M495_RS03875	845547..845840	-	294	WP_020825340.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M495_RS03880	845828..846106	-	279	WP_020825341.1	ribbon-helix-helix protein, CopG family	Antitoxin
M495_RS03885	846196..846579	-	384	WP_041415223.1	oxalurate catabolism protein HpxZ	-
M495_RS03890	846583..847983	-	1401	WP_020825343.1	AtzE family amidohydrolase	-
M495_RS03895	847980..848171	-	192	WP_020825344.1	oxalurate catabolism protein HpxX	-
M495_RS03900	848199..849785	-	1587	WP_020825345.1	gamma-glutamyltransferase	-
M495_RS03905	849932..850771	+	840	WP_020825346.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10918.40 Da
• Isoelectric Point: 6.8772

>T29761 WP_020825340.1 NC_021741:c845840-845547 [Serratia liquefaciens ATCC 27592]
VPQLIWTPAALLDIQRLYQFLAAKDRQAAQKTVASIRSSINILAHHPQAGRPIEDMEIEFREWPNNFGNSGYIIALYHFD
GSTAVLLAVRHQSEAGY

Nucleotide

• Length: 294 bp

>T29761 NC_021741:c845840-845547 [Serratia liquefaciens ATCC 27592]
GTGCCACAACTGATATGGACGCCTGCCGCACTGCTCGATATTCAGCGACTGTACCAATTTCTGGCAGCCAAAGATCGCCA
GGCTGCGCAAAAGACCGTGGCATCCATTCGTAGCAGCATCAATATCCTGGCCCATCATCCTCAGGCCGGTCGGCCCATTG
AAGATATGGAAATTGAATTTAGGGAATGGCCGAACAATTTCGGCAACAGCGGCTATATTATTGCCCTGTATCATTTTGAT
GGCAGCACCGCTGTACTGCTGGCAGTGCGCCATCAAAGTGAAGCCGGTTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10828.97 Da
• Isoelectric Point: 5.6257

>AT29761 WP_020825341.1 NC_021741:c846106-845828 [Serratia liquefaciens ATCC 27592]
MTTATSIKIDDELKQRVQQIAATRQRSAHWIVREAIREYVEREEKREALRKDALQARETYQTNGKHLTQDEADHWLANLE
KGDDTEIPECHN

Nucleotide

• Length: 279 bp

>AT29761 NC_021741:c846106-845828 [Serratia liquefaciens ATCC 27592]
ATGACTACGGCTACATCGATAAAAATTGATGATGAGCTCAAGCAACGGGTGCAACAAATCGCGGCCACGCGTCAGCGAAG
TGCGCACTGGATTGTGCGCGAGGCTATCCGTGAATACGTCGAGCGAGAAGAAAAGCGCGAAGCGCTGCGCAAAGACGCAC
TGCAAGCCAGGGAAACGTATCAGACCAATGGTAAACATCTGACCCAAGACGAGGCTGACCATTGGCTCGCTAATCTGGAA
AAAGGTGATGATACGGAGATACCGGAGTGCCACAACTGA