Detailed information of TA system TA029760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 421049..421629
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M495_RS01960
• Protein ID: WP_020824986.1
• Coordinates: 421345..421629 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7W4F292
• Locus tag: M495_RS01955
• Protein ID: WP_020824985.1
• Coordinates: 421049..421336 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS01930	416787..417872	-	1086	WP_020824980.1	carbon-phosphorus lyase complex subunit PhnI	-
M495_RS01935	417872..418453	-	582	WP_020824981.1	phosphonate C-P lyase system protein PhnH	-
M495_RS01940	418456..418899	-	444	WP_020824982.1	phosphonate C-P lyase system protein PhnG	-
M495_RS01945	418900..419625	-	726	WP_201766292.1	phosphonate metabolism transcriptional regulator PhnF	-
M495_RS01950	419886..420944	+	1059	WP_020824984.1	permease	-
M495_RS01955	421049..421336	+	288	WP_020824985.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
M495_RS01960	421345..421629	+	285	WP_020824986.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
M495_RS01965	421626..422090	-	465	WP_020824987.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
M495_RS25730	422091..422252	+	162	WP_071846549.1	hypothetical protein	-
M495_RS01970	422264..424402	-	2139	WP_020824988.1	anaerobic ribonucleoside-triphosphate reductase	-
M495_RS01975	424686..425594	-	909	WP_020824989.1	LysR family transcriptional regulator	-
M495_RS01980	425699..426223	+	525	WP_020824990.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11117.77 Da
• Isoelectric Point: 4.7160

>T29760 WP_020824986.1 NC_021741:421345-421629 [Serratia liquefaciens ATCC 27592]
MRVEWDEEALRDRERIFDFLYPFNPQAAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLLVLYVVVDDVIKVL
AVAHQREKFPDIEN

Nucleotide

• Length: 285 bp

>T29760 NC_021741:421345-421629 [Serratia liquefaciens ATCC 27592]
ATGCGTGTCGAATGGGATGAAGAAGCGCTACGGGACAGGGAACGTATTTTTGATTTTCTCTATCCTTTTAATCCACAGGC
TGCTGAGCAGGCTGATGCTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACA
GACAGGCGCGTAAGTTATTGGTCAGCCAGGCTTCGTTATTAGTTTTATACGTTGTTGTCGACGACGTGATTAAGGTTTTA
GCCGTTGCTCATCAACGAGAGAAATTCCCCGACATAGAGAACTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11043.40 Da
• Isoelectric Point: 6.4766

>AT29760 WP_020824985.1 NC_021741:421049-421336 [Serratia liquefaciens ATCC 27592]
MESRIQFRIEDETKRLAQKAAEAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Nucleotide

• Length: 288 bp

>AT29760 NC_021741:421049-421336 [Serratia liquefaciens ATCC 27592]
ATGGAAAGTCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAGGGGATCAC
TTTGAGTGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCCACTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTGCCCGTTTGCATGAAGGAAGTGCGGTCTATCTTGACCAGCAACAGGTTGATGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGAGCGAAATACGACCGAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F292