Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3753127..3753656 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M943_RS17620 Protein ID WP_003417760.1
Coordinates 3753399..3753656 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M943_RS17615 Protein ID WP_003417757.1
Coordinates 3753127..3753402 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS22590 3749925..3751362 - 1438 Protein_3453 FAD-binding oxidoreductase -
M943_RS17600 3751465..3751854 + 390 WP_003417745.1 DUF732 domain-containing protein -
M943_RS17605 3751868..3752161 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M943_RS17610 3752158..3753003 - 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M943_RS17615 3753127..3753402 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M943_RS17620 3753399..3753656 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M943_RS17625 3753698..3754888 + 1191 Protein_3459 NADH:flavin oxidoreductase -
M943_RS17630 3755005..3755373 + 369 WP_003417765.1 FHA domain-containing protein -
M943_RS17635 3755370..3755921 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M943_RS17640 3755928..3756509 - 582 WP_003417769.1 ATP/GTP-binding protein -
M943_RS17645 3756490..3756858 - 369 WP_003417772.1 DUF742 domain-containing protein -
M943_RS17650 3756836..3757228 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T29757 WP_003417760.1 NC_021740:3753399-3753656 [Mycobacterium tuberculosis EAI5]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T29757 NC_021740:3753399-3753656 [Mycobacterium tuberculosis EAI5]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT29757 WP_003417757.1 NC_021740:3753127-3753402 [Mycobacterium tuberculosis EAI5]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT29757 NC_021740:3753127-3753402 [Mycobacterium tuberculosis EAI5]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References