Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917856..2918570 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M943_RS13665 Protein ID WP_003413460.1
Coordinates 2918130..2918570 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M943_RS13660 Protein ID WP_003413456.1
Coordinates 2917856..2918143 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS13625 2913278..2913523 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M943_RS13630 2913520..2913924 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M943_RS13635 2914141..2914761 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M943_RS13640 2914772..2915266 + 495 WP_003413444.1 DUF2617 family protein -
M943_RS13645 2915263..2915694 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M943_RS13650 2915719..2916177 + 459 WP_003413451.1 DUF350 domain-containing protein -
M943_RS13655 2916174..2917745 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M943_RS13660 2917856..2918143 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M943_RS13665 2918130..2918570 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M943_RS13670 2918591..2919346 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
M943_RS13675 2919479..2920075 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M943_RS13680 2920083..2920928 - 846 WP_003413466.1 acyl-CoA thioesterase II -
M943_RS13685 2920957..2921856 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M943_RS13690 2921984..2922658 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T29746 WP_003413460.1 NC_021740:2918130-2918570 [Mycobacterium tuberculosis EAI5]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T29746 NC_021740:2918130-2918570 [Mycobacterium tuberculosis EAI5]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT29746 WP_003413456.1 NC_021740:2917856-2918143 [Mycobacterium tuberculosis EAI5]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT29746 NC_021740:2917856-2918143 [Mycobacterium tuberculosis EAI5]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References