Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2395412..2395941 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag M943_RS11220 Protein ID WP_003411124.1
Coordinates 2395412..2395729 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag M943_RS11225 Protein ID WP_003411127.1
Coordinates 2395726..2395941 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS11190 2390549..2391625 + 1077 WP_003904789.1 hypothetical protein -
M943_RS11195 2391622..2391903 + 282 WP_015575159.1 hypothetical protein -
M943_RS11200 2391939..2393012 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
M943_RS11205 2393017..2393547 - 531 WP_003904790.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
M943_RS11210 2393595..2394941 - 1347 WP_020824540.1 M20/M25/M40 family metallo-hydrolase -
M943_RS11220 2395412..2395729 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M943_RS11225 2395726..2395941 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
M943_RS11230 2396196..2397254 + 1059 WP_003904791.1 hypothetical protein -
M943_RS11235 2397384..2397740 - 357 WP_003411130.1 hypothetical protein -
M943_RS11240 2397835..2398617 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
M943_RS11245 2398885..2399175 - 291 WP_003900476.1 YggT family protein -
M943_RS11250 2399337..2399993 - 657 WP_003411133.1 cell division protein SepF -
M943_RS11255 2400059..2400835 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T29740 WP_003411124.1 NC_021740:c2395729-2395412 [Mycobacterium tuberculosis EAI5]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T29740 NC_021740:c2395729-2395412 [Mycobacterium tuberculosis EAI5]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT29740 WP_003411127.1 NC_021740:c2395941-2395726 [Mycobacterium tuberculosis EAI5]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT29740 NC_021740:c2395941-2395726 [Mycobacterium tuberculosis EAI5]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References