Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2198263..2198807 | Replicon | chromosome |
| Accession | NC_021740 | ||
| Organism | Mycobacterium tuberculosis EAI5 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M943_RS10235 | Protein ID | WP_003409896.1 |
| Coordinates | 2198263..2198559 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M943_RS10240 | Protein ID | WP_003409899.1 |
| Coordinates | 2198556..2198807 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M943_RS10180 | 2193296..2193646 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M943_RS10185 | 2193657..2194559 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M943_RS10190 | 2194580..2194771 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M943_RS10195 | 2194772..2195068 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M943_RS10200 | 2195308..2195523 | + | 216 | WP_003409878.1 | antitoxin | - |
| M943_RS10205 | 2195520..2195831 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M943_RS22275 | 2195805..2196326 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| M943_RS10215 | 2196301..2196678 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M943_RS10220 | 2196720..2197169 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M943_RS10225 | 2197166..2197711 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M943_RS10230 | 2197600..2198214 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M943_RS10235 | 2198263..2198559 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M943_RS10240 | 2198556..2198807 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M943_RS10245 | 2198794..2199288 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M943_RS10250 | 2199448..2199855 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M943_RS10255 | 2199859..2200131 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M943_RS10260 | 2200164..2201384 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| M943_RS10270 | 2202283..2203080 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T29732 WP_003409896.1 NC_021740:c2198559-2198263 [Mycobacterium tuberculosis EAI5]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T29732 NC_021740:c2198559-2198263 [Mycobacterium tuberculosis EAI5]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT29732 WP_003409899.1 NC_021740:c2198807-2198556 [Mycobacterium tuberculosis EAI5]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT29732 NC_021740:c2198807-2198556 [Mycobacterium tuberculosis EAI5]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |