Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1965002..1965462 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag M943_RS09160 Protein ID WP_003898996.1
Coordinates 1965214..1965462 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JZ84
Locus tag M943_RS09155 Protein ID WP_003904688.1
Coordinates 1965002..1965214 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS09140 1961480..1962667 - 1188 WP_003898992.1 nitrate transporter NarK -
M943_RS09145 1962954..1963238 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M943_RS09150 1963252..1964934 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M943_RS09155 1965002..1965214 + 213 WP_003904688.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M943_RS09160 1965214..1965462 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
M943_RS09165 1965470..1966207 + 738 WP_003898997.1 hypothetical protein -
M943_RS09170 1966301..1968001 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M943_RS09175 1968286..1968687 - 402 WP_003408538.1 hypothetical protein -
M943_RS09180 1968677..1969288 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T29729 WP_003898996.1 NC_021740:1965214-1965462 [Mycobacterium tuberculosis EAI5]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T29729 NC_021740:1965214-1965462 [Mycobacterium tuberculosis EAI5]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7577.77 Da        Isoelectric Point: 9.3146

>AT29729 WP_003904688.1 NC_021740:1965002-1965214 [Mycobacterium tuberculosis EAI5]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT29729 NC_021740:1965002-1965214 [Mycobacterium tuberculosis EAI5]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGGC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A806JZ84

References