Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1762069..1762682 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag M943_RS08240 Protein ID WP_003407786.1
Coordinates 1762278..1762682 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag M943_RS08235 Protein ID WP_009935474.1
Coordinates 1762069..1762272 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS08205 1757474..1757854 + 381 WP_003407768.1 fumarate reductase subunit C -
M943_RS08210 1757851..1758228 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
M943_RS08215 1758296..1758904 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
M943_RS08220 1759088..1760236 + 1149 Protein_1606 MMPL family transporter -
M943_RS08225 1760246..1760692 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
M943_RS08230 1760727..1762016 + 1290 WP_003407781.1 threonine ammonia-lyase -
M943_RS08235 1762069..1762272 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M943_RS08240 1762278..1762682 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
M943_RS08245 1762699..1764439 - 1741 Protein_1611 malto-oligosyltrehalose trehalohydrolase -
M943_RS08250 1764432..1766729 - 2298 WP_020824505.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T29727 WP_003407786.1 NC_021740:1762278-1762682 [Mycobacterium tuberculosis EAI5]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T29727 NC_021740:1762278-1762682 [Mycobacterium tuberculosis EAI5]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTTCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT29727 WP_009935474.1 NC_021740:1762069-1762272 [Mycobacterium tuberculosis EAI5]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT29727 NC_021740:1762069-1762272 [Mycobacterium tuberculosis EAI5]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References