Detailed information of TA system TA297243

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 4442493..4443153
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: NCTC12023_04709
• Protein ID: SUH99930.1
• Coordinates: 4442740..4443153 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: NCTC12023_04708
• Protein ID: SUH99929.1
• Coordinates: 4442493..4442759 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_04703	4438422..4439894	-	1473	SUH99924.1	6-phospho-beta-glucosidase	-
NCTC12023_04704	4439944..4440324	+	381	SUH99925.1	UPF0267 protein	-
NCTC12023_04705	4440488..4441147	+	660	SUH99926.1	hemolysin	-
NCTC12023_04706	4441155..4441346	+	192	SUH99927.1	Uncharacterised protein	-
NCTC12023_04707	4441263..4442243	-	981	SUH99928.1	Folate-dependent protein for Fe/S clustersynthesis/repair in oxidative stress	-
NCTC12023_04708	4442493..4442759	+	267	SUH99929.1	YgfY	Antitoxin
NCTC12023_04709	4442740..4443153	+	414	SUH99930.1	membrane protein	Toxin
NCTC12023_04710	4443206..4443727	-	522	SUH99931.1	flavodoxin FldB	-
NCTC12023_04711	4443840..4444736	+	897	SUH99932.1	site-specific integrase/recombinase	-
NCTC12023_04712	4444760..4445473	+	714	SUH99933.1	thiol:disulfide interchange protein	-
NCTC12023_04713	4445479..4447212	+	1734	SUH99934.1	single-stranded DNA-specific exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T297243 SUH99930.1 UFRD01000002:4442740-4443153 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T297243 UFRD01000002:4442740-4443153 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT297243 SUH99929.1 UFRD01000002:4442493-4442759 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT297243 UFRD01000002:4442493-4442759 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA