Detailed information of TA system TA297240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/-
• Location: 3816171..3816910
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: NCTC12023_04048
• Protein ID: SUH99305.1
• Coordinates: 3816425..3816910 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: NCTC12023_04047
• Protein ID: SUH99304.1
• Coordinates: 3816171..3816437 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_04042	3811445..3811747	+	303	SUH99300.1	membrane protein	-
NCTC12023_04043	3811886..3812797	+	912	SUH99301.1	glycine-tRNA synthetase subunit alpha	-
NCTC12023_04044	3812807..3814876	+	2070	SUH99302.1	glycine-tRNA synthetase subunit beta	-
NCTC12023_04046	3815505..3815972	+	468	SUH99303.1	acetyltransferase	-
NCTC12023_04047	3816171..3816437	+	267	SUH99304.1	Uncharacterized protein conserved in bacteria	Antitoxin
NCTC12023_04048	3816425..3816910	+	486	SUH99305.1	N-acetyltransferase GCN5	Toxin
NCTC12023_04049	3817282..3817821	-	540	SUH99306.1	putative exported protein	-
NCTC12023_04051	3818496..3818828	-	333	SUH99307.1	putative DNA-binding protein	-
NCTC12023_04052	3819225..3819935	+	711	SUH99308.1	Lipoprotein	-
NCTC12023_04053	3819985..3820959	-	975	SUH99309.1	2-hydroxyacid dehydrogenase	-
NCTC12023_04054	3821178..3821840	-	663	SUH99310.1	outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17703.41 Da
• Isoelectric Point: 9.8719

>T297240 SUH99305.1 UFRD01000002:3816425-3816910 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T297240 UFRD01000002:3816425-3816910 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10141.55 Da
• Isoelectric Point: 4.5256

>AT297240 SUH99304.1 UFRD01000002:3816171-3816437 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADDPVIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT297240 UFRD01000002:3816171-3816437 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGATGCAGCTGCGGAAATCCTTCA
CAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCCTTGACCGCCGTGTATTTAACT
TTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGATCCCGTTATCGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA