Detailed information of TA system TA297236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 2963585..2964101
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NCTC12023_03194
• Protein ID: SUH98515.1
• Coordinates: 2963585..2963869 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: NCTC12023_03195
• Protein ID: SUH98516.1
• Coordinates: 2963859..2964101 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_03191	2958797..2960449	+	1653	SUH98512.1	Trehalose-6-phosphate hydrolase	-
NCTC12023_03192	2960858..2962996	+	2139	SUH98513.1	Anaerobic ribonucleoside-triphosphate reductase	-
NCTC12023_03193	2963117..2963581	+	465	SUH98514.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
NCTC12023_03194	2963585..2963869	-	285	SUH98515.1	RelE toxin	Toxin
NCTC12023_03195	2963859..2964101	-	243	SUH98516.1	bifunctional antitoxin/transcriptional repressor RelB	Antitoxin
NCTC12023_03196	2964179..2966092	-	1914	SUH98517.1	probable licABCH operon regulator Includes: putative phosphotransferase enzyme IIB component;Putative PTS system EIIB component; Includes: RecName:Full=Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component	-
NCTC12023_03197	2966109..2966849	-	741	SUH98518.1	4-Hydroxy-2-oxoglutarate aldolase	-
NCTC12023_03198	2966846..2967964	-	1119	SUH98519.1	L-seryl-tRNA(Sec) selenium transferase-related protein	-
NCTC12023_03199	2967948..2969081	-	1134	SUH98520.1	dihydroorotase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10854.67 Da
• Isoelectric Point: 10.0482

>T297236 SUH98515.1 UFRD01000002:c2963869-2963585 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T297236 UFRD01000002:c2963869-2963585 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT297236 SUH98516.1 UFRD01000002:c2964101-2963859 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT297236 UFRD01000002:c2964101-2963859 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA