Detailed information of TA system TA297235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/-
• Location: 2869337..2869913
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: NCTC12023_03106
• Protein ID: SUH98432.1
• Coordinates: 2869626..2869913 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: NCTC12023_03105
• Protein ID: SUH98431.1
• Coordinates: 2869337..2869639 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_03102	2865847..2867997	+	2151	SUH98428.1	carbon starvation protein	-
NCTC12023_03103	2868092..2868295	+	204	SUH98429.1	putative small protein yjiX	-
NCTC12023_03104	2868306..2869262	+	957	SUH98430.1	Putative GTPases (G3E family)	-
NCTC12023_03105	2869337..2869639	-	303	SUH98431.1	toxin-antitoxin system, antitoxin component	Antitoxin
NCTC12023_03106	2869626..2869913	-	288	SUH98432.1	membrane protein	Toxin
NCTC12023_03107	2870182..2871096	-	915	SUH98433.1	restriction endonuclease	-
NCTC12023_03108	2871294..2874803	+	3510	SUH98434.1	type I restriction enzyme EcoKI subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11294.80 Da
• Isoelectric Point: 9.5894

>T297235 SUH98432.1 UFRD01000002:c2869913-2869626 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T297235 UFRD01000002:c2869913-2869626 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11373.96 Da
• Isoelectric Point: 10.1293

>AT297235 SUH98431.1 UFRD01000002:c2869639-2869337 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT297235 UFRD01000002:c2869639-2869337 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG