Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2268747..2269367 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag NCTC12023_02523 Protein ID SUH97877.1
Coordinates 2269149..2269367 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NCTC12023_02522 Protein ID SUH97876.1
Coordinates 2268747..2269121 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC12023_02519 2263887..2265080 + 1194 SUH97873.1 acriflavin resistance protein A -
NCTC12023_02520 2265103..2265666 + 564 SUH97874.1 acriflavin resistance protein B -
NCTC12023_02521 2265663..2268251 + 2589 SUH97875.1 acriflavin resistance protein B -
NCTC12023_02522 2268747..2269121 + 375 SUH97876.1 Hha toxicity attenuator Antitoxin
NCTC12023_02523 2269149..2269367 + 219 SUH97877.1 hemolysin expression modulating protein Toxin
NCTC12023_02524 2269546..2270097 + 552 SUH97878.1 maltose O-acetyltransferase -
NCTC12023_02525 2270214..2270684 + 471 SUH97879.1 Putative inner membrane protein -
NCTC12023_02526 2270886..2271146 - 261 SUH97880.1 50S ribosomal protein L31 -
NCTC12023_02527 2271371..2272921 + 1551 SUH97881.1 Uncharacterized protein ylaB -
NCTC12023_02529 2273230..2273541 + 312 SUH97882.1 methylated-DNA-[protein]-cysteine S-methyltransferase -
NCTC12023_02530 2273574..2274143 - 570 SUH97883.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T297234 SUH97877.1 UFRD01000002:2269149-2269367 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T297234 UFRD01000002:2269149-2269367 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT297234 SUH97876.1 UFRD01000002:2268747-2269121 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT297234 UFRD01000002:2268747-2269121 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References