Detailed information of TA system TA029722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1382933..1383621
• Replicon: chromosome
• Accession: NC_021740
• Organism: Mycobacterium tuberculosis EAI5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: M943_RS06560
• Protein ID: WP_003406304.1
• Coordinates: 1383190..1383621 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: M943_RS06555
• Protein ID: WP_003406302.1
• Coordinates: 1382933..1383193 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M943_RS06535	1378510..1379334	+	825	WP_051148173.1	trehalose ABC transporter permease SugB	-
M943_RS06540	1379339..1380520	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
M943_RS06545	1380597..1381697	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
M943_RS06550	1381868..1382857	+	990	WP_003406301.1	malate dehydrogenase	-
M943_RS06555	1382933..1383193	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
M943_RS06560	1383190..1383621	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
M943_RS06565	1383644..1385332	-	1689	WP_003910308.1	PE family protein	-
M943_RS06570	1385512..1386372	+	861	WP_003903377.1	hypothetical protein	-
M943_RS06575	1386453..1387283	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
M943_RS06580	1387340..1387633	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
M943_RS06585	1387630..1387899	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T29722 WP_003406304.1 NC_021740:1383190-1383621 [Mycobacterium tuberculosis EAI5]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T29722 NC_021740:1383190-1383621 [Mycobacterium tuberculosis EAI5]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGGCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT29722 WP_003406302.1 NC_021740:1382933-1383193 [Mycobacterium tuberculosis EAI5]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT29722 NC_021740:1382933-1383193 [Mycobacterium tuberculosis EAI5]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6