Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4207523..4208141 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QU406_RS20405 Protein ID WP_001291435.1
Coordinates 4207523..4207741 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QU406_RS20410 Protein ID WP_000344800.1
Coordinates 4207767..4208141 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS20370 (4202810) 4202810..4203382 + 573 WP_000779831.1 YbaY family lipoprotein -
QU406_RS20375 (4203413) 4203413..4203724 - 312 WP_000409908.1 MGMT family protein -
QU406_RS20385 (4204103) 4204103..4204456 + 354 WP_000878135.1 DUF1428 family protein -
QU406_RS20390 (4204498) 4204498..4206048 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QU406_RS20395 (4206212) 4206212..4206682 - 471 WP_000136192.1 YlaC family protein -
QU406_RS20400 (4206798) 4206798..4207349 - 552 WP_000102539.1 maltose O-acetyltransferase -
QU406_RS20405 (4207523) 4207523..4207741 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QU406_RS20410 (4207767) 4207767..4208141 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QU406_RS20415 (4208687) 4208687..4211836 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QU406_RS20420 (4211859) 4211859..4213052 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T297212 WP_001291435.1 NZ_OY019088:c4207741-4207523 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT297212 WP_000344800.1 NZ_OY019088:c4208141-4207767 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References