Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3472719..3473314 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QU406_RS16850 Protein ID WP_000239579.1
Coordinates 3472964..3473314 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QU406_RS16845 Protein ID WP_001223208.1
Coordinates 3472719..3472970 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS16835 (3468384) 3468384..3472163 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QU406_RS16840 (3472166) 3472166..3472507 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QU406_RS16845 (3472719) 3472719..3472970 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QU406_RS16850 (3472964) 3472964..3473314 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QU406_RS16855 (3473394) 3473394..3473924 - 531 WP_000055075.1 inorganic diphosphatase -
QU406_RS16860 (3474234) 3474234..3475190 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QU406_RS16865 (3475330) 3475330..3476832 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QU406_RS16870 (3476846) 3476846..3477868 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T297208 WP_000239579.1 NZ_OY019088:3472964-3473314 [Escherichia coli O25b:H4-ST131]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT297208 WP_001223208.1 NZ_OY019088:3472719-3472970 [Escherichia coli O25b:H4-ST131]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References