Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2430000..2430800 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QU406_RS11965 Protein ID WP_000342452.1
Coordinates 2430000..2430527 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QU406_RS11970 Protein ID WP_001277107.1
Coordinates 2430534..2430800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS11940 (2425076) 2425076..2425843 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QU406_RS11945 (2425840) 2425840..2427117 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QU406_RS11950 (2427114) 2427114..2428040 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QU406_RS11955 (2428088) 2428088..2429197 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QU406_RS11960 (2429620) 2429620..2430003 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QU406_RS11965 (2430000) 2430000..2430527 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QU406_RS11970 (2430534) 2430534..2430800 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QU406_RS11975 (2430949) 2430949..2432052 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QU406_RS11980 (2432323) 2432323..2433177 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QU406_RS11985 (2433422) 2433422..2434480 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QU406_RS11990 (2434473) 2434473..2435141 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T297204 WP_000342452.1 NZ_OY019088:c2430527-2430000 [Escherichia coli O25b:H4-ST131]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT297204 WP_001277107.1 NZ_OY019088:c2430800-2430534 [Escherichia coli O25b:H4-ST131]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References