Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1766792..1767446 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QU406_RS08575 Protein ID WP_000244765.1
Coordinates 1766792..1767199 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QU406_RS08580 Protein ID WP_000354050.1
Coordinates 1767180..1767446 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS08555 (1762749) 1762749..1764482 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QU406_RS08560 (1764488) 1764488..1765198 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QU406_RS08565 (1765223) 1765223..1766119 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QU406_RS08570 (1766231) 1766231..1766752 + 522 WP_001055874.1 flavodoxin FldB -
QU406_RS08575 (1766792) 1766792..1767199 - 408 WP_000244765.1 protein YgfX Toxin
QU406_RS08580 (1767180) 1767180..1767446 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QU406_RS08585 (1767689) 1767689..1768669 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QU406_RS08590 (1768746) 1768746..1769405 - 660 WP_000250275.1 hemolysin III family protein -
QU406_RS08595 (1769569) 1769569..1769880 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QU406_RS08600 (1769925) 1769925..1771358 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T297200 WP_000244765.1 NZ_OY019088:c1767199-1766792 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT297200 WP_000354050.1 NZ_OY019088:c1767446-1767180 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References