Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 6203620..6204878 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QSK41_RS28970 Protein ID WP_003163133.1
Coordinates 6203620..6204375 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QSK41_RS28975 Protein ID WP_003086329.1
Coordinates 6204510..6204878 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS28960 (PAER4782_28930) 6198792..6201335 + 2544 WP_003163132.1 acyl-homoserine-lactone acylase QuiP -
QSK41_RS28965 (PAER4782_28935) 6201490..6202851 - 1362 WP_003081943.1 DNA recombination protein RmuC -
QSK41_RS28970 (PAER4782_28945) 6203620..6204375 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
QSK41_RS28975 (PAER4782_28950) 6204510..6204878 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QSK41_RS28980 (PAER4782_28955) 6204951..6206237 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
QSK41_RS28985 (PAER4782_28960) 6206293..6207786 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QSK41_RS28990 (PAER4782_28965) 6207961..6208437 + 477 WP_003163135.1 hypothetical protein -
QSK41_RS28995 6208440..6208715 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(63-207)

Antitoxin

(23-47)


Sequences


Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T297190 WP_003163133.1 NZ_OX638701:c6204375-6203620 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT297190 WP_003086329.1 NZ_OX638701:c6204878-6204510 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References