Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 5270912..5272133 | Replicon | chromosome |
| Accession | NZ_OX638701 | ||
| Organism | Pseudomonas aeruginosa strain 4782MK isolate 4782MK | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | QSK41_RS24585 | Protein ID | WP_003114949.1 |
| Coordinates | 5271555..5272133 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | QSK41_RS24580 | Protein ID | WP_019371885.1 |
| Coordinates | 5270912..5271466 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QSK41_RS24555 (PAER4782_24470) | 5266480..5267031 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| QSK41_RS24560 (PAER4782_24475) | 5267028..5267426 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| QSK41_RS24565 (PAER4782_24480) | 5267439..5267762 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| QSK41_RS24570 (PAER4782_24485) | 5268093..5268554 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| QSK41_RS24575 (PAER4782_24490) | 5268559..5270754 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| QSK41_RS24580 (PAER4782_24495) | 5270912..5271466 | + | 555 | WP_019371885.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QSK41_RS24585 (PAER4782_24500) | 5271555..5272133 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| QSK41_RS24590 (PAER4782_24505) | 5272241..5273428 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| QSK41_RS24595 (PAER4782_24510) | 5273418..5275589 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| QSK41_RS24600 (PAER4782_24515) | 5275579..5276856 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T297189 WP_003114949.1 NZ_OX638701:5271555-5272133 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20440.60 Da Isoelectric Point: 8.1590
>AT297189 WP_019371885.1 NZ_OX638701:5270912-5271466 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|